Post doc position in translational cancer genomics, Weischenfeldt Research Group, BRIC

Employer
Weischenfeldt research group, BRIC, University of Copenhagen
Location
Copenhagen, Hovedstaden (DK)
Salary
-
Posted
May 31 2021
Position Type
Contract
Organization Type
Academia

University of Copenhagen

Interested in working at the intersection between computational biology and the clinic, with the opportunity to study disease mechanisms and make an impact on patient outcome?

We are looking for two highly motivated, creative, and talented PhD-level computational biologists to join our team. The positions involve studying mutational processes and tumour evolution at bulk and single cell resolution and integrating orthogonal clinical information from cancer patients, commencing 1 October 2021 or after agreement. 

Our group and research
The Weischenfeldt lab has a strong interest in cancer genetics and genomics. We are working on delineating the mutational mechanisms, the contribution of the germline, how it impacts on the clonal evolution of cancer, and the impact on patient outcome. We use computational and experimental approaches including WGS, single-cell, and long-read sequencing together with Hi-C to understand how cancers mutate and evolve, which we are applying to cancer patient material in close collaboration with clinical colleagues.

Project description
The projects involve analysis of genomic and chromatin data from cancer patients including germline and somatic aberrations. Aspects involve analysis of germline-somatic associations and mutational processes in cancer at the single cell level. The project includes executing existing and developing novel computational methods to integrate patient-derived omics data with clinical information. This can involve developing methods and interfaces to implement cancer genomics for clinical decision making.
The successful candidates will be joining a dynamic team of cross-disciplinary cancer researchers, with the aims to uncover disease mechanisms and to identify molecular patterns associated with disease trajectories and outcome in cancer patients. One of the positions involve close interactions with and travel to our collaborating cancer clinic in Berlin.

Starting date: 1 October 2021 or after agreement.

Duration: 2 years with possibility for extension.

Principal supervisor is group leader, assoc prof Joachim Weischenfeldt, BRIC and Rigshospitalet, joachim.weischenfeldt@bric.ku.dk, Phone: +453545 6040

Your job
You will be working with a range of genetic and epigenetic data at bulk and single cell level, and orthogonal patient-associated data in collaboration with other team members. Your job will include analysis of methods to integrate genomics, transcriptomics and epigenomics data set to uncover tumour evolution trajectories and novel therapeutic targets in cancer. You will have the opportunity to develop your own research ideas and approaches. The position involves interdisciplinary research through exchange of ideas and results with clinicians and basic researchers.

Profile
We are looking for highly motivated and enthusiastic scientists with the following competencies and experience:

Essential experience and skills:

  • You have a PhD in computational biology, bioinformatics or related areas
  • You are highly experienced in working with sequencing data and have worked with epigenetic data
  • You have an active interest in cancer
  • Familiar with high-performance compute systems, version control, and statistical programming languages (R, Python, etc.)
  • Proficient communication skills and ability to work in teams
  • Excellent English skills written and spoken

Desirable experience and skills:

  • Experience with machine learning and statistics
  • Experience with tumour evolution reconstruction
  • Experience with single cell and Hi-C analysis
  • Knowledge on mutational mechanisms in cancer
  • Publications as co-author or first author in a related area
  • Fellowships, grants and prizes

Place of employment
The place of employment is at BRIC, University of Copenhagen. We offer creative and stimulating working conditions in dynamic and international research environment. Our research facilities include modern laboratories and access to HPC.
Please read more about our research at https://www.bric.ku.dk/research-groups/Research/weischenfeldt-group/

Terms of employment
Salary, pension and terms of employment will be in accordance with the agreement between the Danish Ministry of Finance and AC (Danish Confederation of Professional Associations). Currently, the monthly salary starts for post docs start at 34,900 DKK/ approx. 4,690 Euro (April 2021-level). Depending on qualifications, a supplement may be negotiated. The employer will pay an additional 17.1 % to your pension fund.

Non-Danish and Danish applicants may be eligible for tax reductions, if they hold a PhD degree and have not lived in Denmark the last 10 years.

The position is covered by the “Memorandum on Job Structure for Academic Staff at the Universities” of June 28, 2013.

Questions
For further information please contact Joachim Weischenfeldt, joachim.weischenfeldt@bric.ku.dk

Foreign applicants may find this link useful: www.ism.ku.dk (International Staff Mobility).

Application procedure
Your online application must be submitted in English by clicking ‘Apply now’ below. Furthermore your application must include the following documents/attachments – all in PDF format:

1. Motivated letter of application (max. one page).
2. CV incl. education, work/research experience, language skills and other skills relevant for the position.
3. A certified/signed copy of a) PhD certificate (if relevant) and b) Master of Science certificate. If the PhD is not completed, a written statement from the supervisor will do.
4. List of publications.

Letters of recommendation
Furthermore, the applicant should provide at least one letter of recommendation. To be taken into consideration, the letter must be signed by the supporting person with institutional letter head and in PDF-format. Please make sure that an easy match between the recommendation letter and the individual applicant is possible.

Application deadline: 28 June 2021, 23.59pm CET
We reserve the right not to consider material received after the deadline, and not to consider applications that do not live up to the abovementioned requirements.

The further process
After the expiry of the deadline for applications, the authorized recruitment manager selects applicants for assessment on the advice of the hiring committee. All applicants are then immediately notified whether their application has been passed for assessment by an unbiased assessor. Once the assessment work has been completed each applicant has the opportunity to comment on the part of the assessment that relates to the applicant him/herself.

You can read about the recruitment process at http://employment.ku.dk/faculty/recruitment-process/

The applicant will be assessed according to the Ministerial Order no. 242 of 13 March 2012 on the Appointment of Academic Staff at Universities.

Interviews are expected to be held in week 31 and 32.

University of Copenhagen wish to reflect the diversity of society and welcome applications from all qualified candidates.


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Part of the International Alliance of Research Universities (IARU), and among Europe’s top-ranking universities, the University of Copenhagen promotes research and teaching of the highest international standard. Rich in tradition and modern in outlook, the University gives students and staff the opportunity to cultivate their talent in an ambitious and informal environment. An effective organisation – with good working conditions and a collaborative work culture – creates the ideal framework for a successful academic career.