Gene Editing Research Scientist

Location
Boston, Massachusetts (US)
Salary
Salary commensurate with experience.
Posted
May 21 2021
Position Type
Full Time
Organization Type
Pharma
Job Type
Staff Scientist

 Gene Editing Research Scientist

Company Overview:

Vertex has established a new site in the Boston area where research, development, and clinical manufacturing for cell and genetic therapies is primarily based. Cell and genetic therapies represent two rapidly emerging therapeutic modalities with the potential to treat—and even cure—several serious diseases, including sickle cell disease, Duchenne muscular dystrophy and type 1 diabetes. Further investment in a research site specifically designed to advance these programs will be key to Vertex’s continued and sustained leadership in these exciting, cutting-edge therapeutic areas. At Vertex Cell and Genetic Therapies (VCGT) our research teams bring together the best biology, technologies, and enhanced manufacturing capabilities to ensure we deliver transformative therapies to patients as quickly as possible. 

Job Summary:

Our Gene Editing Research Team is hiring for several Research Scientist positions. The ideal candidates should have extensive experience designing and executing complex research projects to support the development of CRISPR-Cas9-based gene editing therapies. The Scientists will have the opportunity to perform state-of-the-art research, lead various studies, and work together with other Scientists and Research Associates to develop novel gene editing tools and to evaluate and advance lead assets for our therapeutic programs. The candidates are expected to display a high level of passion, drive and determination, complete work in a resourceful and proactive manner and will be able to design studies and troubleshoot results to achieve projected goals.

Key Responsibilities:

  • Participate in the design, development, and implementation of novel therapeutic gene editing platforms to advance our lead programs
  • Apply cutting-edge molecular and cell biology techniques to one or several of the following research areas:
    • CRISPR guide RNA screens, gene editing efficiency assessment and OFF-target evaluation using high-throughput Next-Generation-Sequencing-based assays
    • Design, evaluation, and optimization of AAV Vectors for CRISPR-Cas9 gene editing
    • Development and implementation of human cell-based platforms (ex. iPSCs) to support gene editing therapeutic programs
  • Develop and perform specialized assays to evaluate novel gene editing tools and candidate therapeutic assets
  • Systematically collect, interpret, and present data; effectively communicate findings to various stakeholders
  • Make recommendations to guide project decisions and new research activities
  • Perform advanced experimental troubleshooting and study design optimization
  • Identify, prioritize, and introduce relevant emerging technologies in field of expertise to advance the existing technology platforms and create/maintain a competitive advantage
  • Effectively collaborate with a fully integrated team to facilitate the success of projects

Key Requirements:

  • PhD in Cell or Molecular Biology, Genetics, or related discipline
  • Advanced expertise in the latest molecular and cellular biology and/or gene editing techniques
  • Demonstrated scientific productivity as evidenced by a strong publication record in top tier journals or equivalent industry accomplishments
  • Excellent communication skills with proven ability to build open and collaborative relationships and work effectively as a member of a multidisciplinary team
  • Extensive experience in one or several of the following areas is a strong plus: CRISPR-Cas9 gene editing, next generation sequencing, AAV Vector Biology, Induced Pluripotent Stem Cell (iPSC) Biology and/or mammalian cell culture-based assays
  • Exemplary work ethic and commitment to self-development and self-improvement
  • Strong interpersonal and organizational skills

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