Senior Scientific Researcher/Principal Scientific Researcher

94080, South San Francisco
May 20 2021
Position Type
Full Time
Organization Type

Join a Team that Lives to Improve Lives
People come to Genentech from across disciplines and across the world to solve our most challenging medical conditions. You’ll find inspiration in our passion for biotechnology, our purpose to positively impact the lives of millions of patients and our dedication to our people. Joining Genentech means being part of a tradition of inquiry that will change the world. It means embracing our failures as much as our successes. It requires a willingness to look beyond the edge of what's possible. And a focus on doing the day-to-day work that makes great science happen. 

The following opportunity exists in our South San Francisco, CA headquarters:

Senior Scientific Researcher/Principal Scientific Researcher


We are looking for an exceptional Senior Scientific Researcher/Principal Scientific Researcher to join the Biochemical and Cellular Pharmacology (BCP) Department within Genentech's Research and Early Development (gRED). The successful candidate will be responsible for supporting biochemical and cellular characterization of protein therapeutics for various therapeutic areas, including oncology, cancer immunology, inflammation and neuroscience. More specifically, the individual will develop, validate and execute biochemical and cell-based assays to characterize and screen biologic therapeutics in vitro and ex vivo, to support lead-finding and optimization efforts, as well as mechanistic characterization of drug candidates.


The successful individual will be developing and implementing medium and high-throughput in vitro biochemical and cell-based functional assays to identify and characterize drug candidates. He/she will be expected to independently design, implement, troubleshoot, and contribute to the data analysis and present work to project teams. In addition, the individual will be expected to incorporate lab automation in his/her workflow and harness novel technologies in assay development.

The candidate will function as part of a multi-disciplinary project team that will coordinate with Antibody Engineering, Protein Chemistry, Therapeutic Areas, and Translational Research groups to advance the projects’ lead molecules.

Who You Are

  • B.S./M.S. degree in Immunology, Biochemistry, Cell Biology, or a related field with 3 to 6+years of relevant research experience in academia, biotechnology and/or pharmaceutical industry;
  • Proven expertise in the design, development, validation, and execution of biochemical and cell-based assays.
  • Experience with the mammalian cell culture, as well as primary cells culture.
  • Familiarity with cell biology techniques such as Western blot, Flow cytometry, Immunofluorescence, high-content microscopy, and image analysis.
  • Experience with CRISPR gene editing and 3D spheroid or will be a plus.
  • Experience with CRISPR gene editing and 3D spheroid or organoids will be a plus.
  • Ability to work independently to design, execute, and interpret experiments, and also to collaborate well with project teams
  • Record of achievement including publications that demonstrate expertise and knowledge.
  • Excellent teamwork, oral/written communication, time management, analytical, critical thinking, and organizational skills

Who We Are
Genentech, a member of the Roche group and founder of the biotechnology industry, is dedicated to pursuing groundbreaking science to discover and develop medicines for people with serious and
life-threatening diseases. To solve the world's most complex health challenges, we ask bigger questions that challenge our industry and the boundaries of science to transform society. Our transformational discoveries include the first targeted antibody for cancer and the first medicine for primary progressive multiple sclerosis.

Diversity and Inclusion (D&I) are critical to the success of our company and our impact on society.  We believe that by championing diversity of background, thought and experience, we can foster a sense of belonging and provide an environment where every employee feels valued, included, and able to contribute their best for the patients we serve. We’re focused on attracting, retaining, developing and advancing our people to their full potential by rewarding bold ways of thinking and integrating inclusive behaviors into every aspect of our work. 

The next step is yours. To apply today, click on the "Apply online" button.

Genentech is an equal opportunity employer & prohibits unlawful discrimination based on race, color, religion, gender, sexual orientation, gender identity/expression, national origin/ancestry, age, disability, marital & veteran status. For more information about equal employment opportunity, visit our Genentech Careers page.

At Genentech, we share salary ranges with applicants during the recruiting process, if requested. Third party salary estimates may not be accurate or up-to-date.

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