Pfizer

Senior Scientist, T Cell Immuno-Oncology

Employer
Pfizer
Location
La Jolla, California
Salary
Competitive
Posted
May 16 2021
Ref
4811257
Position Type
Full Time
Organization Type
Pharma
Job Type
Senior Scientist
ROLE SUMMARY

The Cancer Immunology Discovery group at Pfizer is seeking a highly motivated and creative Senior Scientist to join the T cell activation and PDx resistance team to identify and evaluate novel therapies in the fields of Cancer Immunotherapy and Immune Checkpoint Biology. The candidate will provide scientific and technical expertise and work closely with other disciplines across Pfizer to initiate and drive discovery research programs into early clinical development. Specifically, the candidate will identify unique tumor-specific micro-environmental cues that impact T cell function, differentiation, and trafficking using a variety of tools including, molecular, cellular, and biochemical techniques, as well as modern imaging techniques, systems immunology, bioinformatics, and preclinical in vitro and in vivo models. The successful candidate will be a subject matter expert motivated to innovate and succeed in a fast-paced, collaborative environment.

ROLE RESPONSIBILITIES
  • Discover and develop new small and large molecule therapeutic modalities for cancer immunotherapy.
  • Design and perform studies to evaluate the anatomical distribution, persistence, and function of antigen-specific T cells in preclinical models of cancer.
  • Design and execute mechanistic, PD, and biomarker studies for preclinical-stage therapies using in vivo mouse models and ex vivo assays, including but not limited to multi-parameter flow cytometry, gene expression analysis techniques, and functional assays.
  • Work in a matrixed environment and collaborate with multiple disciplines to identify and pursue the most promising drug candidates.
  • Participate and present in internal and external project meetings as well as at site and cross-site meetings.
  • Communicate experimental findings accurately and concisely in both oral and written formats.


BASIC QUALIFICATIONS
  • PhD in Immunology, Oncology, or related discipline or MS with 7+ years' relevant post-graduate experience.
  • Ability to independently design, plan, execute, and interpret experiments.
  • Ability to manage an independent research program with minimal supervision.
  • Expertise in standard immunologic techniques.
  • Excellent organization skills and good verbal and written communication.
  • The ability to work independently and as part of a team in a fast-paced environment.
  • Strong motivation with a dedicated work ethic.


PREFERRED QUALIFICATIONS
  • Strong track record of scientific accomplishments in the field of T cell biology, including function, differentiation, and/or memory development.
  • Broad technical expertise in assessing T cell phenotype and function in vivo/ex vivo (flow cytometry, qRT-PCR, MSD, confocal microscopy).
  • Experience investigating T cell-specific inhibitory/co-stimulatory molecules and their associated signal transduction pathways (western blot, reporter assays).
  • Experience with genome editing approaches in cell lines/primary cells (CRISPR, lentiviral transduction).
  • Experience with murine/human T cell functional assays (e.g. activation, differentiation, proliferation, cytotoxic and suppression assays).
  • Experience with murine tumor and/or infectious disease models.


PHYSICAL/MENTAL REQUIREMENTS
  • Ability to perform complex data analysis.
  • Ability to interpret and apply results in the context of Pfizer programs and published literature.
  • Strong interpersonal skills and a desire to succeed in a team setting.


OTHER JOB DETAILS
  • Eligible for Relocation Package
  • Eligible for Employee Referral Bonus


#LI-PFE

Sunshine Act

Pfizer reports payments and other transfers of value to health care providers as required by federal and state transparency laws and implementing regulations. These laws and regulations require Pfizer to provide government agencies with information such as a health care provider's name, address and the type of payments or other value received, generally for public disclosure. Subject to further legal review and statutory or regulatory clarification, which Pfizer intends to pursue, reimbursement of recruiting expenses for licensed physicians may constitute a reportable transfer of value under the federal transparency law commonly known as the Sunshine Act. Therefore, if you are a licensed physician who incurs recruiting expenses as a result of interviewing with Pfizer that we pay or reimburse, your name, address and the amount of payments made currently will be reported to the government. If you have questions regarding this matter, please do not hesitate to contact your Talent Acquisition representative.

EEO & Employment Eligibility

Pfizer is committed to equal opportunity in the terms and conditions of employment for all employees and job applicants without regard to race, color, religion, sex, sexual orientation, age, gender identity or gender expression, national origin, disability or veteran status. Pfizer also complies with all applicable national, state and local laws governing nondiscrimination in employment as well as work authorization and employment eligibility verification requirements of the Immigration and Nationality Act and IRCA. Pfizer is an E-Verify employer.

Research and Development

#LI-PFE

Similar jobs

Similar jobs