Postdoctoral Scholar Immunology
The Iritani laboratory at the University of Washington has immediate availability for a Postdoctoral scholar in Cellular and Molecular Immunology. The start date would be Fall/Winter 2021 or sooner. The overall goals of the laboratory are to define the roles of specific signaling proteins in the development, functions, and transformation of immune cells. Potential projects will focus on utilizing murine models to define how loss-of-function mutations in specific genes result in Primary Immunodeficiency Diseases (PIDs) and autoimmunity. Project 1 involves investigating the mechanisms of how LOF mutations in Fnip1 alter immunometabolism and lymphocyte development (see Park et al., Immunity (PMID 22608497); Park et al., PNAS (PMID 24785297); Reyes et al., PNAS (PMID 24785297); Iritani et al., Blood (PMID 33507298)). Project 2 focuses on investigating how LOF mutations in a hematopoietic cell-specific actin regulatory protein called Hem-1 alter the development and functions of macrophages, T cells, or B cells (see Park et al., Journal of Experimental Medicine (PMID 19015308); Suwankitwat et al., Journal of Experimental Medicine (PMID 33600594); Peters et al Nat Genetics (PMID 28892060). Loss-of-function variants in Hem-1 and Fnip1 were recently discovered in 2020 to result in PIDs in humans. Successful candidates will utilize a variety of innovative approaches including metabolomics, transcriptomics, epigenomics, proteomics, live cell imaging, and humanized mice.
The University of Washington is one of the world’s most preeminent public universities, located in beautiful Seattle. In 2020, the UW was ranked 10th by the US News and World Report’s Best Global Universities.
Postdoctoral scholars are represented by UAW 4121 and are subject to the collective bargaining agreement, unless agreed exclusion criteria apply. For more information, please visit the University of Washington Labor Relations website.