Post-Doctoral Research Fellow - Stem Cell Research
The Rush University Alzheimer's Disease Center (RADC) is a leading experimental and epidemiological center for the study of Alzheimer's disease. Over the past decade, the RADC has carried out numerous community-based cohort studies and generated multi-omic data from human specimens (https://www.radc.rush.edu/). An ongoing effort is to employ a human cell-based culture system to validate AD candidate genes identified from our multi-omic data, and ultimately to bridge the gap between systems biology and drug discovery. As part of this major expansion, we are seeking a highly motivated candidate for a Postdoctoral position in Stem Cell Biology.
Our group has published in Science, Nature and Cell, and we expect that your research will be of similar high impact. To facilitate these results, you will be assisted in utilizing the most clinically detailed and extensive collection of Alzheimer's brain resources in the world. You will be supported by a faculty team of 30 statisticians, neuropathologists, systems, and experimental biologists, as well as staff of 100+ who are gathering clinical and experimental detail on Alzheimer's cohorts. Examples of the rich data can be seen here and, in many 1000,+ citation papers. Additionally, this position offers: Priority on quickly producing high-impact publications, taking advantage of unique Alzheimer's datasets at Rush University. Thousands of post-mortem tissues available for person-specific AD models. Deeply phenotyped sample origins, with multiple omics, cognitive testing, and neuroimaging. Sole access to the latest sequencing and cellular phenotyping equipment Pursue highly novel targets and follow effects wherever they lead
Scientific focus in a flat organizational structure, with stable funding. Career development and grant-writing opportunities alongside highly successful scientists
- Lead and perform range of lab-based experiments including reprogramming human somatic cells into induced pluripotent stem cells, stem cell banking and validations, stem cell differentiation into disease-relevant cell types, generating 2D and 3D culture models, phenotyping diseased cells with cellular, molecular and functional assays.
- Oversee the day to day organization of different components of the projects.
Work collaboratively with other RADC teams who are working on related research questions.
Required Job Qualifications:
- PhD or MD or equivalent degree in the fields of Stem Cell Biology, Developmental Neurobiology, Neuroscience, Molecular biology, Cell Biology, or related fields.
- Excellent skills and experience in human iPSC derivation, stem cell culture and 2D/3D neural differentiation as well as directly conversion of somatic cells to neural lineages.
- Strong experience in designing cellular and molecular assays to phenotype "disease-in-a-dish".
- Experience in calcium imaging and multielectrode arrays are highly desirable.
- Experience in genome editing and next gene sequencing is a plus.
- Demonstrated skills in project planning, organization, analysis, and communication.
- Proven ability to work independently and in collaborative team environments.
Please apply thru the link below or contact Dr. Yangling Wang at Yanling_Wang@rush.edu
- Rush was recently ranked first for Quality and Accountability among US academic medical centers in a study conducted by the health care performance improvement company Vizient.
- The Association for the Accreditation of Human Research Protection Programs (AAHRPP) has awarded Rush full accreditation for three years. Rush is one of the first academic medical centers in Illinois to receive this accreditation.
- As an academic medical center, Rush University Medical Center in Chicago, Illinois, is committed to advancing medical knowledge through research. Investigators at Rush are involved in more than 1,600 projects, including hundreds of clinical studies to test the effectiveness and safety of new therapies and medical devices, as well as to expand scientific and medical knowledge.
- Rush was recently ranked among the top 20 hospitals in the nation by U.S. News & World Report.
- Eleven Rush programs were recently ranked among the nation's best by U.S. News & World Report.
- Rush University is home to one of the first medical colleges in the Midwest and one of the nation's top-ranked nursing colleges, as well as graduate programs in allied health, health systems management and biomedical research.
Rush is an equal opportunity employer. We evaluate qualified applicants without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability, veteran status, and other legally protected characteristics.