Genetic Data Architect

Collegeville, Pennsylvania
April 15 2021
Other, Other
Organization Type
We are seeking a genomic data architect with interdisciplinary experience, including a track record of supporting innovative, high quality research by managing and modelling large volumes of genetic and genomic data and results in a distributed database and analytical environment.

GSK aims to improve the number of successful late stage clinical trials for innovative medicines, by both identifying and advancing drug targets that have strong evidence of a causal role in disease biology. The Human Genetics team leverages major scientific and technological advances, including investment in biobanks linked to large-scale human health databases, cutting-edge informatics platforms, breakthrough understanding of biological pathways, functional genomics capabilities built upon rapid progress in gene editing, and leading industry-academia partnerships, in order to identify the best targets and to continue evaluation of targets through their life in the pipeline.

The successful candidate will work in a multidisciplinary, collaborative and scientifically driven environment, interacting with GSK scientists and key academic collaborators to advance drug discovery and clinical development in multiple disease areas. This research will leverage industry-leading data and compute resources, to address important drug discovery and development challenges, to directly impact GSK's R&D pipeline, and to publish in top scientific journals.

The selected Genomic Data Architect will:
  • Develop and maintain a robust data platform to efficiently house and represent critical human genetic, genomic, and clinical/phenotypic data, to inform target selection and validation decisions across a range of disease areas.
  • Leverage the opportunities and efficiencies afforded by access to hybrid cloud-based, distributed ecosystem of database technologies
  • Participate closely with GSK genetics analysts and data scientists, recommending data structures to enable novel genetic analyses, leveraging large volumes of data on modern storage and computational platforms.
  • Be responsible for monitoring data integrity and security and addressing database issues that arise

Why you?

Basic Qualifications:

We are looking for professionals with these required skills to achieve our goals:
  • Masters or equivalent experience in genetics, bioinformatics, or related life sciences applications.
  • Experience with genetic and genomic data types, including public genetic databases and results data from high-throughput genetic assays ( e.g. UK Biobank, Gnomad, etc.)
  • 5+ years of experience in complex data architecture design, and familiarity with applications of FAIR principles
  • Hands-on maintenance of database systems and data manipulation using SQL, working within a POSIX CLI environment
  • Experience with distributed database technologies ( e.g. the Apache Hadoop/Hive ecosystem).
  • Experience with management of large volumes of a variety of genetic/genomic data and results

Preferred Qualifications:

If you have the following characteristics, it would be a plus:
  • Ability to discuss genomic data types and analyses used in early target discovery.
  • Experience with data and/or results specifically from large scale genetic association studies (e.g. GWAS or PheWAS) or large scale functional genomic data.
  • Experience with complex longitudinal human clinical/phenotype data, e.g. from electronic health records, epidemiological cohorts, or clinical trials.

Why GSK?

Our values and expectationsare at the heart of everything we do and form an important part of our culture.

These include Patient focus, Transparency, Respect, Integrity along with Courage, Accountability, Development, and Teamwork. As GSK focuses on our values and expectations and a culture of innovation, performance, and trust, the successful candidate will demonstrate the following capabilities:
  • Agile and distributed decision-making - using evidence and applying judgement to balance pace, rigour and risk.
  • Managing individual and team performance.
  • Committed to delivering high quality results, overcoming challenges, focusing on what matters, execution.
  • Implementing change initiatives and leading change.
  • Sustaining energy and well-being, building resilience in teams.
  • Continuously looking for opportunities to learn, build skills and share learning both internally and externally.
  • Developing people and building a talent pipeline.
  • Translating strategy into action - a compelling narrative, motivating others, setting objectives and delegation.
  • Building strong relationships and collaboration, managing trusted stakeholder relationships internally and externally.
  • Budgeting and forecasting, commercial and financial acumen.



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GSK is an Equal Opportunity Employer and, in the US, we adhere to Affirmative Action principles. This ensures that all qualified applicants will receive equal consideration for employment without regard to race, color, national origin, religion, sex, pregnancy, marital status, sexual orientation, gender identity/expression, age, disability, genetic information, military service, covered/protected veteran status or any other federal, state or local protected class.

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