Sr. Principal Scientist - Cell Biology, Oncology Drug Discovery

Boulder, Colorado
May 14 2021
Position Type
Full Time
Organization Type

Pf izer-Boulder, CO (formerly Array BioPharma) is focused on the discovery, development and commercialization of targeted small molecule drugs to treat patients afflicted with cancer. Array BioPharma is known for its approval and launch of BRAFTOVI (encorafenib) and MEKTOVI (binimetinib) to treat patients with BRAF mutated melanoma. These products were granted Breakthrough Therapy Designation by the FDA for BRAF mutated CRC.

With more than 300 days a year of sunshine, Boulder is a paradise in the West! Hikers, bikers, foodies, beer enthusiasts, art and theater lovers, and more feel right at home here.Visit to discover what we love about Boulder.Many Pfizer colleagues live just outside of Boulder in Longmont, Westminster, Lafayette, and other surrounding communities and have commutes of only 15 to 20 minutes.

The individual will contribute to preclinical drug discovery programs from target selection candidate identification and characterization. They will leverage their expertise in oncology cell biology to identify new targets that align with the site strategy, develop assays to support drug discovery programs, guide programs, and oversee the design and execution of compound mechanism-of-action studies.

  • Identifies strategic and tactical challenges for each of the drug discovery programs that they support, and identify experiments to address these challenges
  • Design and oversee studies to characterize the biological consequences of a given mechanism of action to enable generation of a robust clinical development plan to identify relevant cancer types, target patient population, potential combination strategies and mechanisms of resistance
  • Directly supervise and mentor 2-3 scientists supporting multiple discovery programs
  • Maintain state-of-the-art technical knowledge
  • Monitor all relevant literature with respect to potential and current targets
  • Contribute to written and oral presentations

  • PhD in biological sciences, minimum 6-7years' industry experience with a focus in oncology and kinases
  • Strong familiarity with small molecule drug discovery from lead identification to candidate nomination
  • Significant experience supervising, mentoring and developing the careers of scientists of all experience levels
  • Strong leader who understands their roles and responsibilities and works to empower their direct reports and project team members to contribute to the overall success of the efforts they support
  • Highly refined oral and written communication skills with the ability to effectively articulate key concepts to all levels of the organization as well as externally
  • Ability to work in a fast-paced environment with a high degree of independence to effectively address both strategic and tactical challenges, leveraging their solid understanding of cell biology and kinase oncology
  • Recognized company-wide as a subject matter and/or technical expert in one or more areas
  • Candidate demonstrates a breadth of diverse leadership experiences and capabilities including: the ability to influence and collaborate with peers, develop and coach others, oversee and guide the work of other colleagues to achieve meaningful outcomes and create business impact.

  • Eligible for Relocation Package
  • Eligible for Employee Referral Bonus


The annual base salary for this position ranges from $106,300 to $177,100. In addition, this position offers an annual bonus with a target of 17.5% of the base salary and eligibility to participate in our share based long term incentive program. Benefits offered include a retirement savings plan, paid vacation, holiday and personal days, paid caregiver/parental and medical leave, and health benefits to include medical, prescription drug, dental and vision coverage in accordance with the terms and conditions of the applicable plans.

Sunshine Act

Pfizer reports payments and other transfers of value to health care providers as required by federal and state transparency laws and implementing regulations. These laws and regulations require Pfizer to provide government agencies with information such as a health care provider's name, address and the type of payments or other value received, generally for public disclosure. Subject to further legal review and statutory or regulatory clarification, which Pfizer intends to pursue, reimbursement of recruiting expenses for licensed physicians may constitute a reportable transfer of value under the federal transparency law commonly known as the Sunshine Act. Therefore, if you are a licensed physician who incurs recruiting expenses as a result of interviewing with Pfizer that we pay or reimburse, your name, address and the amount of payments made currently will be reported to the government. If you have questions regarding this matter, please do not hesitate to contact your Talent Acquisition representative.

EEO & Employment Eligibility

Pfizer is committed to equal opportunity in the terms and conditions of employment for all employees and job applicants without regard to race, color, religion, sex, sexual orientation, age, gender identity or gender expression, national origin, disability or veteran status. Pfizer also complies with all applicable national, state and local laws governing nondiscrimination in employment as well as work authorization and employment eligibility verification requirements of the Immigration and Nationality Act and IRCA. Pfizer is an E-Verify employer.

Research and Development


Similar jobs

Similar jobs