Senior Scientist, Biophysical Chemistry

Andover, Massachusetts
May 13 2021
Position Type
Full Time
Organization Type
Job Type
Senior Scientist

The qualified candidate will join the Analytical R&D organization and contribute to the development of biological therapeutic candidates. Within Analytical R&D, the candidate will join the Mass Spectrometry and Biophysical Characterization (MSBC) group. The qualified candidate will be responsible for implementing methods of analysis for the detailed characterization of proteins, peptides, vaccines, and oligosaccharides.


Responsible for utilizing the following techniques to confirm the intended structure of drug candidates: NMR, CD, FTIR, DSC, AUC, SEC-MALS, DLS, AFM and chromatography. The characterization of higher order structure (HOS) and high molecular mass (HMMS) are key elements of the position. The above skills will be applied to a large platform of projects in all stages of development.

Apply various biophysical techniques in characterizing proteins, nucleic acids, polysaccharides, synthetic polymers, viral capsids, nanoparticles, small molecule metabolites, etc. to support understanding the biotherapeutic products and bioprocess development.

Carrying out NMR experiments, including data acquisition and processing, qualitative and quantitative NMR analysis, structure determination of unknowns and summarize this information in written and/or oral reports.

Participate in project teams and collaborate with colleagues from different functional lines to provide characterization support to advance portfolio.

Provide high quality analytical results for regulatory filing and participate in composing regulatory documents.

  • PhD in physical biochemistry, analytical biochemistry, biochemistry, chemistry, or relate field, with 0-3 years of post-doctoral or industrial experience in working with biological molecules by using a variety of biophysical tools.
  • Expertise with NMR data analysis software is required

  • Scientific knowledge of general analytical techniques (HPLC, FTIR, CD, AUC, CD) is desirable
  • Proficient in acquisition, processing, and interpretation of 1D and 2D NMR data
  • Hands-on experience with NMR instruments preferred
  • Skills and knowledge in other molecular spectroscopy techniques such as AFM, FTIR spectroscopy, light scattering spectroscopy, etc., is highly desired.
  • Familiarity about separation technology including liquid chromatography, field flow fractionation, etc. is also desired.
  • Knowledge in polymer science, pharmaceutical sciences, statistical analysis, structural biology and molecular modeling will be considered.
  • Previous employment in the pharmaceutical industry would be highly beneficial.
  • In addition to good communication and writing skills, the applicant should also be able to work both independently and collaboratively in a team-based, fast-paced environment.

  • Last Day to Apply: May 19, 2021
  • Eligible for Relocation: Yes
  • Eligible for Employee Referral Bonus: Yes

Sunshine Act

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EEO & Employment Eligibility

Pfizer is committed to equal opportunity in the terms and conditions of employment for all employees and job applicants without regard to race, color, religion, sex, sexual orientation, age, gender identity or gender expression, national origin, disability or veteran status. Pfizer also complies with all applicable national, state and local laws governing nondiscrimination in employment as well as work authorization and employment eligibility verification requirements of the Immigration and Nationality Act and IRCA. Pfizer is an E-Verify employer.

Research and Development


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