Pfizer

Senior Scientist, Rare Disease Gene Therapy

Employer
Pfizer
Location
Cambridge, Massachusetts
Salary
Competitive
Posted
May 13 2021
Ref
4813698
Position Type
Full Time
Organization Type
Pharma
Job Type
Senior Scientist
Role Summary

Pfizer's Rare Disease Research Unit (RDRU) is focused on developing therapeutic solutions for patients with rare disorders, including those associated with central nervous system diseases and inborn errors of metabolism. We are seeking a laboratory-based Senior Scientist to be part of an interdisciplinary team to execute preclinical studies in support of Pfizer's gene therapy portfolio. This individual will have oversight of the design and evaluation of next generation gene delivery vectors for the treatment of CNS diseases. Individuals with expertise in one or more of the following technical areas are highly desirable: gene regulation, RNA interference and splicing, non-coding RNA and/or AAV expression cassette design. The Senior Scientist will work independently in the laboratory as well as a member of cross-functional and collaborative project teams. In addition, the individual will use their scientific judgment in making decisions within their area of expertise, proactively gather input from colleagues and develop novel processes to ensure efficient and timely execution of the team's deliverables.

Role Responsibilities

• Design and execute preclinical AAV studies evaluating vector performance in neurological diseases; Work will include building, optimizing and testing next generation AAV transgene expression cassettes.

• Design and execute assays utilizing in vitro models (primary cells, IPSCs) to support preclinical model systems and enable target identification and assay development

• Generate quality data and lead aspects of AAV-based gene therapy projects in the RDRU pipeline.

• Partner with other Pfizer Research and Development teams, including other discovery lines in Rare Disease, and those in drug metabolism and safety to develop translational preclinical packages with the goal of identifying gene therapy drug candidates.

• Support high-priority projects in the RDRU portfolio

• Work with external collaborators and Contract Research Organizations.

Basic Qualifications

• Ph.D. in the life sciences with preferably > 2 years of post-doctoral experience.

• Scientific training and background in cellular and molecular biology, disease pathophysiology and AAV virology.

• Hands-on experience with AAV transgene construct design, molecular cloning, testing vector transduction pharmacology in vitro and/or in vivo is preferred, plate-based cellular assays

• Basic understanding of neurological diseases and neuroanatomy is desirable.

• Strong communication skills and ability to work as part of a team.

• Evidence of scientific accomplishments in the form of publications and presentations.

• Experience supporting a multidisciplinary project team including generating high-quality data in a time-sensitive environment, assimilating new information from multiple sources, and effectively communicating with internal and external scientists.

• Creative, self-motivated and the ability to work independently including analysis and troubleshooting of experimental results and reviewing literature to formulate new approaches.

Other Job Details:
  • Last Date to Apply for Job: June 7, 2021
  • Eligible for Employee Referral Bonus: YES
  • Relocation support available


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Research and Development