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Associate Scientist Early Bioprocess Development

Employer
Pfizer
Location
Pearl River, New York
Salary
Competitive
Closing date
May 20, 2021

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Discipline
Health Sciences, Drug Development
Position Type
Full Time
Organization Type
All Industry, Pharma
POSITION SUMMARY

The primary purpose of this position is to design, plan, and execute the diverse purification / recovery operations required for the production of the various vaccine candidates using broad range of fractionation methods (centrifugation, ultra / diafiltration, etc.), and chromatographic techniques (affinity, ion exchange, hydrophobic interaction, immobilized metal, mixed mode chromatography, etc.) It is also expected that the incumbent will perform analysis / characterization of isolated macromolecules with various bioanalytical methodologies. The incumbent will be expected to summarize, evaluate the study results, develop and test new hypotheses to improve the fundamental understanding of recovery and purification processes. Careful documentation of work and presentation of data is required.

POSITION RESPONSIBILITIES
  • Utilizing strong scientific and engineering approach, develop, optimize, and scale-up recovery/purification processes for isolation of vaccine candidates up to pilot plant scale.
  • Collaborate with colleagues towards introduction of new technologies to improve and accelerate downstream process development and improve process efficiency.
  • Work effectively with team in development and execution of continuous purification processes.
  • Collaborate with colleagues within Vaccine Research and Development organization including Bioprocess Fermentation, Analytical, Conjugation, and Formulation Development groups.
  • Present problems and propose solutions in discussions with group members.
  • Plan and prioritize related recovery / purification activities.
  • Independently analyze, interpret, and provide conclusion and present experimental data.
  • Keep abreast of scientific/ technological development by participating in scientific meetings/ seminars and through regular scientific review.
  • Utilize new technologies and establish those technologies to improve purification / recovery capabilities of process development group.
  • Where applicable, perform job responsibilities in compliance with GLP and all other regulatory agency requirements.
  • Satisfactorily complete all GLP and safety training in compliance with departmental requirements and follow appropriate safety practices in the workplace.
  • Perform timely notebook entries and review for completed experiments.
  • Perform other duties as assigned.


TECHNICAL SKILLS REQUIREMENTS
  • Knowledge and ability to independently design, plan, and execute purification / recovery activities.
  • Proficiency and ability to utilize various techniques such as FPLC / HPLC, UV-Vis, CD, fluorescence spectroscopy to isolate and, when necessary, characterize purified vaccine candidates.
  • Independently analyze and provide conclusions regarding experimental data generated.


ORGANIZATIONAL RELATIONSHIPS
  • The incumbent will interact with Bioprocess Fermentation, Analytical, Conjugation, and Formulation Development groups for support of process development, sample analysis, conjugation, and formulation activities.


QUALIFICATIONS
  • BS or M.S. in Chemical/Biochemical Engineering, Biochemistry, or related discipline with 0 - 3 years relevant experience.
  • Experience isolating/purifying proteins from both microbial and mammalian systems is preferred.
  • Experience in recovery and purification processes, experience in a process development.
  • Good written and verbal communication capabilities. Ability to work independently.
  • Working knowledge of statistical methods for DOE design and data analysis (e.g., JMP or Design Expert software).
  • Proficiency with personal computers including word processing, spreadsheets, PowerPoint and relevant scientific software is desirable.
  • Strong verbal and written communication skills are required.


PHYSICAL/MENTAL REQUIREMENTS
  • Must be able to lift at least 25 lbs.


Other Job Details:
  • Last Date to Apply for Job: May 21 , 2021
  • Eligible for Employee Referral Bonus: YES


Sunshine Act

Pfizer reports payments and other transfers of value to health care providers as required by federal and state transparency laws and implementing regulations. These laws and regulations require Pfizer to provide government agencies with information such as a health care provider's name, address and the type of payments or other value received, generally for public disclosure. Subject to further legal review and statutory or regulatory clarification, which Pfizer intends to pursue, reimbursement of recruiting expenses for licensed physicians may constitute a reportable transfer of value under the federal transparency law commonly known as the Sunshine Act. Therefore, if you are a licensed physician who incurs recruiting expenses as a result of interviewing with Pfizer that we pay or reimburse, your name, address and the amount of payments made currently will be reported to the government. If you have questions regarding this matter, please do not hesitate to contact your Talent Acquisition representative.

EEO & Employment Eligibility

Pfizer is committed to equal opportunity in the terms and conditions of employment for all employees and job applicants without regard to race, color, religion, sex, sexual orientation, age, gender identity or gender expression, national origin, disability or veteran status. Pfizer also complies with all applicable national, state and local laws governing nondiscrimination in employment as well as work authorization and employment eligibility verification requirements of the Immigration and Nationality Act and IRCA. Pfizer is an E-Verify employer.

Research and Development

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