Scientist - Biology, Rare Disease

Cambridge, Massachusetts
May 11 2021
Position Type
Full Time
Organization Type
Why Patients Need You

Pfizer's purpose is to deliver breakthroughs that change patients' lives. Research and Development is at the heart of fulfilling Pfizer's purpose as we work to translate advanced science and technologies into the therapies and vaccines that matter most. Whether you are in the discovery sciences, ensuring drug safety and efficacy or supporting clinical trials, you will apply cutting edge design and process development capabilities to accelerate and bring the best in class medicines to patients around the world.

What You Will Achieve

As a Scientist, you will be at the center of our operations and you'll find that everything we do, every day, is in line with an unwavering commitment to quality. You will be part of a team that is addressing the critical task of rejuvenating our pipeline with innovative, differentiated First-In-Class/ Only-In-Class programs in the years to come.

Pfizer's Rare Disease Research Unit (RDRU) is focused on developing therapies for rare inherited diseases, including rare muscle, cardiac, and neurological disorders. The successful candidate will be a member of the rare cardiac disease research team and will be responsible for establishing preclinical biochemical- and cell-based assays to enable the efficacy of lead compounds to be established.

In vivo (rodent) experience is desired, to assist in the establishment of rare cardiac disease models.

The candidate is expected to have excellent problem solving, critical thinking, and presentation skills (written and oral) and will need to effectively communicate with internal and external partners.

It is your innovative scientific temperament that will help in making Pfizer ready to achieve new milestones and help patients across the globe.

How You Will Achieve It
  • Contribute to achievement of goals of the team and influence at the work group/project team level.
  • Design and conduct experiments that advance the development of candidate therapies for rare cardiac diseases.
  • Perform experimental studies, carry out data analyses and interpretation, record results in an electronic lab notebook, and stay abreast of novel relevant findings from the literature.
  • Prepare and present experimental results to project teams.
  • Interface with internal interdisciplinary teams.
  • Support in vitro work for other projects in the RDRU portfolio as needed.
  • Comply with all safety training and good laboratory practices.


  • B.S. with 6+ years of experience in biochemistry, cell biology, or a related discipline.
  • Familiarity with standard cell and molecular biology methods including but not limited to cell culture, siRNA and plasmid transfections, immunoassays such as ELISAs and western blotting, and quantitative real-time PCR.
  • Must be willing to work with live rodents and cells/tissues of human origin.
  • Ability to use appropriate software to perform analysis of data.
  • Excellent organization and planning skills, the ability to work in a fast-paced environment independently or as part of a team, strong motivation with a dedicated work ethic.
  • Excellent verbal and written communication skills.
  • Creativity, self-motivation and the ability to work independently including analysis and troubleshooting of experimental results and reviewing literature to formulate new approaches.

  • Master's degree and 4+ years of relevant experience.
  • Hands-on experience working with in vitro and in vivo models of heart disease.
  • Experience with culturing induced pluripotent stem cells and cardiomyocytes.
  • Experiencewith in vitrocardiomyocyte function assessments.
  • Experience in rodent cardiac physiology assessments.
  • Experience working in or collaborating with industry.

Other Job Details
  • Last Date to Apply: May 24, 2021
  • Eligible for Employee Referral Bonus
  • Eligible for Relocation Assistance

Sunshine Act

Pfizer reports payments and other transfers of value to health care providers as required by federal and state transparency laws and implementing regulations. These laws and regulations require Pfizer to provide government agencies with information such as a health care provider's name, address and the type of payments or other value received, generally for public disclosure. Subject to further legal review and statutory or regulatory clarification, which Pfizer intends to pursue, reimbursement of recruiting expenses for licensed physicians may constitute a reportable transfer of value under the federal transparency law commonly known as the Sunshine Act. Therefore, if you are a licensed physician who incurs recruiting expenses as a result of interviewing with Pfizer that we pay or reimburse, your name, address and the amount of payments made currently will be reported to the government. If you have questions regarding this matter, please do not hesitate to contact your Talent Acquisition representative.

EEO & Employment Eligibility

Pfizer is committed to equal opportunity in the terms and conditions of employment for all employees and job applicants without regard to race, color, religion, sex, sexual orientation, age, gender identity or gender expression, national origin, disability or veteran status. Pfizer also complies with all applicable national, state and local laws governing nondiscrimination in employment as well as work authorization and employment eligibility verification requirements of the Immigration and Nationality Act and IRCA. Pfizer is an E-Verify employer.

Research and Development


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