Senior Scientist, BioMedicine Design

Cambridge, Massachusetts
May 09 2021
Position Type
Full Time
Organization Type
Job Type
Senior Scientist
We are seeking a candidate specializing in protein mass spectrometry to work in the BioMedicine Design (BMD) line of the Medicinal Sciences Organization. In this role the candidate will investigate, develop, and implement LC/MS and LC/MS/MS based strategies for the structural characterization of recombinant protein biotherapeutics. The candidate will work with project teams to advance biotherapeutic candidates in the discovery space to support the large molecule discovery portfolio across Pfizer.

  • Provide mass spectrometry-based protein/peptide characterization support for the detailed structural analysis of proteins and conjugates.
  • Elucidation of the major and minor product isoforms from intact protein, subunit, and peptide mapping analyses, as well as identification of unknown (low-level) species using biochemical methods and/or secondary MS techniques.
  • Expected involvement in the design and execution of these studies and the ability to run experiments independently.
  • Responsible for generating top quality mass spectrometry data packages for the characterization of complex biologic candidates such as proteins, antibodies, conjugates, bispecifics, and other engineered biomolecules.
  • Drive technology innovation; evaluate and apply cutting edge technologies and methods for molecular characterization.
  • Work closely with cross-functional teams including therapeutic discovery teams, protein expression and purification groups, biophysics, and the development organization to plan and execute deliverables.

  • PhD with 0-3 years of pharma experience or Master's Degree with 3-6 years of pharma experience with degree focused in biochemistry, chemistry or biophysics.
  • Hands on experience with a wide range of protein mass spectrometry-based technologies and their applications for protein/peptide characterizations, for example, using methods such as LC/MS and LC/MS/MS analysis for the analysis of biological samples, de novo protein/antibody sequence analysis, peptide mapping, PTM characterization and glycosylation analysis.
  • Experience and knowledge in operation of modern mass spectrometry platforms and associated data analysis packages.
  • Experience in maintaining and upkeep of various mass spectrometry platforms such as Thermo Fisher Orbitrap Eclipse, Q-Tof, and Bruker Maxis.
  • Strong communication skills, written and oral and ability to work in a team.
  • Prior experience in therapeutic protein discovery and biochemistry research.
  • Demonstrated track record of independent research and scientific publications in peer review journals.


  • MS and MS/MS based method development experience is highly desired for implementing more informative and efficient approaches to product characterization.
  • Experience in glycosylation analysis a positive, but not required.
  • Experience in characterization of AAV highly desirable, but not required.

Additional Job Information
  • Last Date to Apply: May 17, 2021
  • #LI-PFE

Sunshine Act

Pfizer reports payments and other transfers of value to health care providers as required by federal and state transparency laws and implementing regulations. These laws and regulations require Pfizer to provide government agencies with information such as a health care provider's name, address and the type of payments or other value received, generally for public disclosure. Subject to further legal review and statutory or regulatory clarification, which Pfizer intends to pursue, reimbursement of recruiting expenses for licensed physicians may constitute a reportable transfer of value under the federal transparency law commonly known as the Sunshine Act. Therefore, if you are a licensed physician who incurs recruiting expenses as a result of interviewing with Pfizer that we pay or reimburse, your name, address and the amount of payments made currently will be reported to the government. If you have questions regarding this matter, please do not hesitate to contact your Talent Acquisition representative.

EEO & Employment Eligibility

Pfizer is committed to equal opportunity in the terms and conditions of employment for all employees and job applicants without regard to race, color, religion, sex, sexual orientation, age, gender identity or gender expression, national origin, disability or veteran status. Pfizer also complies with all applicable national, state and local laws governing nondiscrimination in employment as well as work authorization and employment eligibility verification requirements of the Immigration and Nationality Act and IRCA. Pfizer is an E-Verify employer.

Research and Development