Senior Scientist, T Cell Immuno-Oncology

La Jolla, California
May 07 2021
Position Type
Full Time
Organization Type
Job Type
Senior Scientist

The Cancer Immunology Discovery group at Pfizer is seeking a highly motivated and creative Senior Scientist to join the T cell activation and PDx resistance team to identify and evaluate novel therapies in the fields of Cancer Immunotherapy and Immune Checkpoint Biology. The candidate will provide scientific and technical expertise and work closely with other disciplines across Pfizer to initiate and drive discovery research programs into early clinical development. Specifically, the candidate will identify unique tumor-specific micro-environmental cues that impact T cell function, differentiation, and trafficking using a variety of tools including, molecular, cellular, and biochemical techniques, as well as modern imaging techniques, systems immunology, bioinformatics, and preclinical in vitro and in vivo models. The successful candidate will be a subject matter expert motivated to innovate and succeed in a fast-paced, collaborative environment.

  • Discover and develop new small and large molecule therapeutic modalities for cancer immunotherapy.
  • Design and perform studies to evaluate the anatomical distribution, persistence, and function of antigen-specific T cells in preclinical models of cancer.
  • Design and execute mechanistic, PD, and biomarker studies for preclinical-stage therapies using in vivo mouse models and ex vivo assays, including but not limited to multi-parameter flow cytometry, gene expression analysis techniques, and functional assays.
  • Work in a matrixed environment and collaborate with multiple disciplines to identify and pursue the most promising drug candidates.
  • Participate and present in internal and external project meetings as well as at site and cross-site meetings.
  • Communicate experimental findings accurately and concisely in both oral and written formats.

  • PhD in Immunology, Oncology, or related discipline or MS with 7+ years' relevant post-graduate experience.
  • Ability to independently design, plan, execute, and interpret experiments.
  • Ability to manage an independent research program with minimal supervision.
  • Expertise in standard immunologic techniques.
  • Excellent organization skills and good verbal and written communication.
  • The ability to work independently and as part of a team in a fast-paced environment.
  • Strong motivation with a dedicated work ethic.

  • Strong track record of scientific accomplishments in the field of T cell biology, including function, differentiation, and/or memory development.
  • Broad technical expertise in assessing T cell phenotype and function in vivo/ex vivo (flow cytometry, qRT-PCR, MSD, confocal microscopy).
  • Experience investigating T cell-specific inhibitory/co-stimulatory molecules and their associated signal transduction pathways (western blot, reporter assays).
  • Experience with genome editing approaches in cell lines/primary cells (CRISPR, lentiviral transduction).
  • Experience with murine/human T cell functional assays (e.g. activation, differentiation, proliferation, cytotoxic and suppression assays).
  • Experience with murine tumor and/or infectious disease models.

  • Ability to perform complex data analysis.
  • Ability to interpret and apply results in the context of Pfizer programs and published literature.
  • Strong interpersonal skills and a desire to succeed in a team setting.

  • Eligible for Relocation Package
  • Eligible for Employee Referral Bonus


Sunshine Act

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EEO & Employment Eligibility

Pfizer is committed to equal opportunity in the terms and conditions of employment for all employees and job applicants without regard to race, color, religion, sex, sexual orientation, age, gender identity or gender expression, national origin, disability or veteran status. Pfizer also complies with all applicable national, state and local laws governing nondiscrimination in employment as well as work authorization and employment eligibility verification requirements of the Immigration and Nationality Act and IRCA. Pfizer is an E-Verify employer.

Research and Development


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