Principal Scientist - Assay Development, High Throughput Screening

Cambridge, Massachusetts
May 07 2021
Position Type
Full Time
Organization Type
Why Patients Need You

Pfizer's purpose is to deliver breakthroughs that change patients' lives. Research and Development is at the heart of fulfilling Pfizer's purpose as we work to translate advanced science and technologies into the therapies and vaccines that matter most. Whether you are in the discovery sciences, ensuring drug safety and efficacy or supporting clinical trials, you will apply cutting edge design and process development capabilities to accelerate and bring the best in class medicines to patients around the world.

What You Will Achieve

We are seeking an experienced, highly motivated scientist to become part of a team focusing on assay development and high throughput screening for the generation and identification of novel biotherapeutics. The individual will participate in efforts to develop and integrate cell-based functional assays including, but not limited to, reporter gene, downstream signaling, internalization, proliferation, & apoptosis to address unmet screening needs. Qualified candidates will develop each assay for high-throughput capacity through the use of robotics, liquid handlers and relevant screening platforms. The successful individual will collaborate with and support various research units for the development of biotherapeutics, and thrive in a fast-paced, team environment. In this position, the successful candidate will work within a matrix, across a portfolio of programs, collaborating with multiple groups including the research units (discovery biology) and several partner lines.

How You Will Achieve It

  • Develop cell-based functional assays for high-throughput screening
  • Troubleshoot experimental design and assay optimization
  • Conversion of current biochemical and cell-based assays into HT format
  • Extensive experience in the integration and establishment of high-throughput integrated automation system, liquid handlers, screening platforms and data capture systems
  • Critically analyze experimental data and present results at internal meetings.
  • Collaborate with and support the relevant biology research units
  • Ensure all tasks and responsibilities are performed according to scientific and ethical standards and accurately documented in lab notebook.



  • PhD in biology, biochemistry or related field with 4+ years of research experience in assay development and high throughput screening, with the ability to succeed in a collaborative, highly matrixed environment.
  • Strong background in assay development techniques for all major target classes including GPCRs, Enzymes, transporters, ion channels, etc.
  • Experience with homogenous assay development including HTRF/LANCE/DELFIA/Alpha Screen
  • Experience in molecular biology and cell line manipulation
  • Cell culture expertise (primary and immortalized)
  • Prior experience with high-throughput screening, automation and liquid handling platforms
  • A highly motivated, self-directed scientist with the demonstrated ability to multitask, prioritize work and manage a number of projects
  • Exceptional communication skills, attention to detail and customer focus
  • Demonstrated ability to work effectively as part of a team and to adapt to ambiguity and change.

Other Job Details:
  • Eligible for Employee Referral Bonus
  • Eligible for Relocation Package

Sunshine Act

Pfizer reports payments and other transfers of value to health care providers as required by federal and state transparency laws and implementing regulations. These laws and regulations require Pfizer to provide government agencies with information such as a health care provider's name, address and the type of payments or other value received, generally for public disclosure. Subject to further legal review and statutory or regulatory clarification, which Pfizer intends to pursue, reimbursement of recruiting expenses for licensed physicians may constitute a reportable transfer of value under the federal transparency law commonly known as the Sunshine Act. Therefore, if you are a licensed physician who incurs recruiting expenses as a result of interviewing with Pfizer that we pay or reimburse, your name, address and the amount of payments made currently will be reported to the government. If you have questions regarding this matter, please do not hesitate to contact your Talent Acquisition representative.

EEO & Employment Eligibility

Pfizer is committed to equal opportunity in the terms and conditions of employment for all employees and job applicants without regard to race, color, religion, sex, sexual orientation, age, gender identity or gender expression, national origin, disability or veteran status. Pfizer also complies with all applicable national, state and local laws governing nondiscrimination in employment as well as work authorization and employment eligibility verification requirements of the Immigration and Nationality Act and IRCA. Pfizer is an E-Verify employer.

Research and Development


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