Investigator - LC-MS Protein Characterization

Collegeville, PA
April 14 2021
Other, Other
Organization Type
The candidate will be primarily responsible for developing mass spec-based strategies & methods (e.g. LC-MS and LC-MS/MS) and perform analysis for the characterization and comparability evaluation of therapeutic proteins. They will also develop and apply advanced methods and techniques, including immunoprecipitations and/or other small-scale purifications. The candidate is also expected to develop other analytical and/or biochemical methods to deepen the understanding of protein structure -function relationships, and participate in supporting FTIH through commercial biopharmaceutical process development and manufacturing.

The mass spec group is well equipped with modern instrumentation including Synapt G2S with both H/DX and IM, Xevo G2-XS, Orbitrap Fusion Tribrid, Orbitrap XL, Exploris 480, Eclipse Tribrid, Q Exactive Plus, 2D-NanoUPLC, Nano-UPLC, UPLC and many other supporting instrumentation and associated data analysis software.

Why you?

Basic Qualifications:

We are looking for professionals with these required skills to achieve our goals:
  • MS with more than 5+ years of experience in biotech or pharmaceutical industry or a Ph.D.
  • Experience in protein characterization mass spectrometry, with hands-on experience on various high-resolution accurate mass LC-MS instruments operation, nano-LC fluidics and LC-MS/MS methods, data processing software and workflows.
  • Experience in mass spectrometry instrumentation, maintenance, and troubleshooting
  • Prior experience in developing cutting-edge LC-MS/MS workflows for therapeutic proteins in combination (co-formulation) is highly preferred
  • .

Preferred Qualifications:

If you have the following characteristics, it would be a plus:
  • Experience in analysis of protein therapeutics using platform assays like intact/reduced, peptide mapping and advanced/novel technologies
  • Excellent scientific and working knowledge in structure and function of protein glycosylation, prior experience in glycan and/or glycomics analysis
  • In-depth knowledge and hands-on experience in various separation techniques such as immunoprecipitation or other in vitro purification, CE, SEC, IEX and HPLC/UPLC
  • Experience in supporting FTIH through commercial stage of biopharmaceutical development
  • The candidate is expected to be highly motivated with excellent communication skills, both written and verbal. Candidate should be an instinctive team player with excellent people skills.

Why GSK?

Our values and expectations are at the heart of everything we do and form an important part of our culture.

These include Patient focus, Transparency, Respect, Integrity along with Courage, Accountability, Development, and Teamwork. As GSK focuses on our values and expectations and a culture of innovation, performance, and trust, the successful candidate will demonstrate the following capabilities:

  • Operating at pace and agile decision-making - using evidence and applying judgement to balance pace, rigour and risk.
  • Committed to delivering high quality results, overcoming challenges, focusing on what matters, execution.
  • Continuously looking for opportunities to learn, build skills and share learning.
  • Sustaining energy and well-being.
  • Building strong relationships and collaboration, honest and open conversations.
  • Budgeting and cost-consciousness.

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GSK is an Equal Opportunity Employer and, in the US, we adhere to Affirmative Action principles. This ensures that all qualified applicants will receive equal consideration for employment without regard to race, color, national origin, religion, sex, pregnancy, marital status, sexual orientation, gender identity/expression, age, disability, genetic information, military service, covered/protected veteran status or any other federal, state or local protected class.

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