Investigator, In vitro CV/CNS Safety Pharmacologist - Electrophysiology

Collegeville, PA
March 29 2021
Organization Type
Are you looking for a toxicology opportunity to work on the design and execution of studies to discover, understand, model, simulate and create a new drug molecule? If so, this is the role for you.

As Toxicology Manager Professional you will be responsible for conducting and summarizing toxicology safety studies on new drug substances as well as working on strategies and programs. You will also provide specialized scientific veterinary, and translational expertise for drug discovery and development.

This role will provide YOU the opportunity to lead key activities to progress YOUR career. These responsibilities include some of the following:
  • Safety Pharmacology exploration in strategic focus area of complex in vitro models.
  • Expand on platform experience of applying hiPS for safety (CV & CNS) to build capability in addressing gaps in contractility and structural cardiac toxicity and key assays for CNS Strategy (e.g., organs on chips)
  • Shape future in vitro Safety Pharmacology Off-Target Strategy: deliver follow-up tests for assessing functional consequences of off-target activity and applying bioinformatics/in silico models for mechanistic understanding. Involved in further development of the hiPSC-CM MEA assay e.g. development of a chronic assay, implementation of CiPA protocol.
  • Enhance off-target ion channel screening capabilities; including CNS voltage/ligand-gated channels, CV voltage gated channels.
  • Work in the CV/CNS discipline to support target and compound safety through design, conduct, interpretation and communication of in vitro studies. Involves integration of experimental data with other safety pharmacology and project data to develop a mechanistic understanding for a CV/CNS effect and its likely translation to human.
  • Work as part of the Global Safety Pharmacology team, with colleagues on other sites

Why you?

Basic Qualifications:

We are looking for professionals with these required skills to achieve our goals:
  • MS with 5 years experience working in the in vitro CV and/or CNS area or PhD
  • Experience designing, conducting and interpreting in vitro CV and/or CNS functional assays, screening strategies, electrophysiology and/or imaging. Mammalian cell culture and maintenance of cell lines, primary and stem cell derived cells. Including the use of multi-electrode arrays (MEA).
  • Experience of working as part of discovery project teams, and experience incorporating a drug safety strategy into a project strategy.
  • Experience with integration of large data sets from multiple sources, to develop and communicate an understanding of the issue and associated risk.
  • Experience leading scientific projects.
  • Experience mentoring/coaching junior colleagues.
  • Experience working with or as part of discovery project teams as a drug safety representative.
  • Experience representing Pharma or interacting with external partners (e.g. CROs, academic groups).
  • Experience with laboratory instrumentation and data collection tools. Experience with the application of statistical approaches to the analysis of in vitro data.

Preferred Qualifications:

If you have the following characteristics, it would be a plus:

  • Scientific expertise knowledge
  • Ability to solve problems
  • Knowledge of regulatory requirements and drug development process
  • Leadership skills
  • Ability to work in a matrix environment
  • Effective communicator
  • Project management experience
  • Ability to interact with outs internal and external

Why GSK?

Our values and expectationsare at the heart of everything we do and form an important part of our culture.

These include Patient focus, Transparency, Respect, Integrity along with Courage, Accountability, Development, and Teamwork. As GSK focuses on our values and expectations and a culture of innovation, performance, and trust, the successful candidate will demonstrate the following capabilities:
  • Operating at pace and agile decision-making - using evidence and applying judgement to balance pace, rigour and risk.
  • Committed to delivering high quality results, overcoming challenges, focusing on what matters, execution.
  • Continuously looking for opportunities to learn, build skills and share learning.
  • Sustaining energy and well-being
  • Building strong relationships and collaboration, honest and open conversations.
  • Budgeting and cost-consciousness


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GSK is an Equal Opportunity Employer and, in the US, we adhere to Affirmative Action principles. This ensures that all qualified applicants will receive equal consideration for employment without regard to race, color, national origin, religion, sex, pregnancy, marital status, sexual orientation, gender identity/expression, age, disability, genetic information, military service, covered/protected veteran status or any other federal, state or local protected class.

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