Senior Principal Scientist, Medicinal Chemistry

Boulder, Colorado
May 02 2021
Position Type
Full Time
Organization Type

Pfizer Boulder R&D is looking to grow its drug discovery and chemical biology capabilities. We are seeking a results-driven synthetic organic chemist to help evaluate and integrate new medicinal chemistry strategies, and to support our biology departments through the design and synthesis of tool compounds, novel tags, and chemical probes.

In this role, you will be a key contributor to our efforts to identify new biological targets and suitable medicinal chemistry strategies to drug them. You will be expected to use your expertise and creativity to design, synthesize, and refine compounds that enable lead screening campaigns, evaluation of biological targets, and feasibility studies around novel technologies.

Based in Colorado: With more than 300 days a year of sunshine, Boulder is a paradise in the West!Visit to discover what we love about Boulder. Many colleagues live in or just outside of Boulder and have commutes of only 15 to 30 minutes.

  • Provide chemistry support for several projects in parallel by designing new tool compounds and synthetically executing designed routes in the lab.
  • Influence the projects through troubleshooting and advocating novel approaches and methods.
  • Collaborate across functional areas with other departments
  • Evaluate complex data sets
  • Keep current with the drug discovery literature as pertinent to ongoing projects and overall objective of the role
  • Present results and conclusions in a clear and concise manner to project management
  • Mentor/lead/manage other chemistry team members
  • Publish and present internally and externally to Pfizer

  • Doctorate level degree in relevant area of science, or BS/MS with equivalent industrial experience
  • Minimum 8 years of relevant experience in the pharmaceutical industry
  • Ability to scientifically challenge others in a constructive manner and demonstrates exceptional team working skills
  • Track record of delivering high impact contributions to medicinal chemistry projects
  • Expert working knowledge of organic chemistry

  • Knowledge in biochemistry and/or biology

Candidate demonstrates a breadth of diverse leadership experiences and capabilities including: the ability to influence and collaborate with peers, develop and coach others, oversee and guide the work of other colleagues to achieve meaningful outcomes and create business impact.

  • Ability to perform data analysis
  • Ability to safely work in a chemistry lab (standing, lifting, walking, bending)

For roles based in Colorado:

The annual base salary for this position ranges from $106,300 to $177,100 . In addition, this position offers an annual bonus with a target of 17.5% of the base salary and eligibility to participate in our share based long term incentive program. Benefits offered include a retirement savings plan, paid vacation, holiday and personal days, paid caregiver/parental and medical leave, and health benefits to include medical, prescription drug, dental and vision coverage in accordance with the terms and conditions of the applicable plans.

Additional Job Details:
  • Last Date to Apply: May 7, 2021
  • Relocation support available
  • Eligible for employee referral bonus


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EEO & Employment Eligibility

Pfizer is committed to equal opportunity in the terms and conditions of employment for all employees and job applicants without regard to race, color, religion, sex, sexual orientation, age, gender identity or gender expression, national origin, disability or veteran status. Pfizer also complies with all applicable national, state and local laws governing nondiscrimination in employment as well as work authorization and employment eligibility verification requirements of the Immigration and Nationality Act and IRCA. Pfizer is an E-Verify employer.

Research and Development

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