Sr. Scientist, Gene Therapy Cell Culture Development

Chesterfield, Missouri
April 30 2021
Position Type
Full Time
Organization Type
Why Patients Need You

Pfizer's purpose is to deliver breakthroughs that change patients' lives. Research and Development is at the heart of fulfilling Pfizer's purpose as we work to translate advanced science and technologies into the therapies and vaccines that matter most. The Senior Scientist in cell culture process development will help drive the advancement of Pfizer's gene therapy production platform and progression of gene therapy portfolio programs. In this role, you will apply cutting edge design and process development capabilities to accelerate and bring the best in class medicines to patients around the world.

What You Will Achieve

As a Senior Scientist, you will be at the center of our operations and you'll find that everything we do, every day, is in line with an unwavering commitment to quality. The Senior Scientist in upstream process development will help drive the advancement of Pfizer's gene therapy production platform and progression of gene therapy portfolio programs. The incumbent should be highly motivated, results-oriented, and a self-starter who demonstrates personal accountability for outcomes and thrives on increasing levels of responsibility. As a member of the Bioprocessing R&D development department, the Senior Scientist will design and execute cell culture experiments and drive innovative collaborations to develop robust, scalable, and highly productive upstream processes for recombinant viral vector manufacture. The successful candidate will work with a team of scientists from diverse functional areas to enable the delivery of life-changing gene therapy medicine to patients.

You will be recognized as a technical expert and a scientific contributor. With your deep knowledge of the discipline, you will be an active team member whose decisions impact the project. You will be using your scientific judgment to adapt standard methods and techniques by applying prior work experience. You will be forecasting and planning resource requirements for your project team. Your creativity in developing novel processes and new ideas will be used frequently. You will undertake mentoring activities to guide team members.

It is your innovative scientific temperament that will help in making Pfizer ready to achieve new milestones and help patients across the globe.

How You Will Achieve It
  • Design and execute mammalian cell culture experiments with the goal of developing robust and scalable processes for viral vectors with appropriate product quality attributes for clinical applications.
  • Demonstrates leadership and capability to mentor junior colleagues, and fosters a team environment.
  • Ability to troubleshoot scientific and technical challenges, and contribute to their resolution.
  • Analyze and communicate experimental results both orally and in written reports to colleagues and management.
  • Ensures effective, high-quality, timely and appropriate documentation in laboratory notebooks and internal Technical Reports.
  • Contribute to equipment procurement, laboratory set up and organization.
  • Contributes to a safe, efficient and effective lab environment with personal accountability.


  • PhD degree (0-3 years experience), MS (5+ years), or BS (8+ yrs) in a biological or engineering discipline (chemical engineering, biochemistry, molecular biology, or equivalent)
  • 0 - 3 years of experience in laboratory research, preferably in recombinant protein expression, process development, and/or bioprocess manufacturing.
  • Demonstrated ability to drive for results and generate innovative solutions with minimum supervision.Applicants should be self-motivated, organized, capable of working independently, and in a collaborative environment.

  • Experience with recombinant viral vector process development is a plus.
  • The successful candidate will possess strong oral and written communication skills. Experience in transferring biotherapeutic processes to pilot plants or manufacturing organizations, and knowledge of data acquisition and controls systems in these environments is a plus.
  • Working knowledge of lab scale bioreactor systems and automated process control equipment.
  • Strong attention to detail.
  • Ability to execute detailed experimental plans, record procedures, analyze data, and present results.
  • Experience with statistical experimental design and analysis of biological processes.
  • Agility in a fast paced team environment to help meet the company goals.

  • This position will require standing for long periods of time in a laboratory setting. Occasional lifting of equipment may be required.

  • Occasional travel to vendor, Pfizer or contract manufacturing/research sites may be required.

Other Job Details:
  • Last Date to Apply for Job: May 14, 2021
  • Eligible for Employee Referral Bonus: YES


Sunshine Act

Pfizer reports payments and other transfers of value to health care providers as required by federal and state transparency laws and implementing regulations. These laws and regulations require Pfizer to provide government agencies with information such as a health care provider's name, address and the type of payments or other value received, generally for public disclosure. Subject to further legal review and statutory or regulatory clarification, which Pfizer intends to pursue, reimbursement of recruiting expenses for licensed physicians may constitute a reportable transfer of value under the federal transparency law commonly known as the Sunshine Act. Therefore, if you are a licensed physician who incurs recruiting expenses as a result of interviewing with Pfizer that we pay or reimburse, your name, address and the amount of payments made currently will be reported to the government. If you have questions regarding this matter, please do not hesitate to contact your Talent Acquisition representative.

EEO & Employment Eligibility

Pfizer is committed to equal opportunity in the terms and conditions of employment for all employees and job applicants without regard to race, color, religion, sex, sexual orientation, age, gender identity or gender expression, national origin, disability or veteran status. Pfizer also complies with all applicable national, state and local laws governing nondiscrimination in employment as well as work authorization and employment eligibility verification requirements of the Immigration and Nationality Act and IRCA. Pfizer is an E-Verify employer.

Research and Development


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