Skip to main content

This job has expired

Downstream Scientist

Employer
GSK
Location
Rockville, MD
Salary
Competitive
Closing date
May 6, 2021

View more

Discipline
Health Sciences, Drug Development
Organization Type
All Industry, Pharma
Are you energized by a challenging role in biology, where scientific demand is driving team growth? If so, this Downstream Scientist role would be a great opportunity to consider.

The Early Development and SAM Center of Excellence, Technical Research & Development, GSK Vaccines is focused on developing vaccine candidates from discovery to development. We are looking for a motivated scientist with a strong experience in purification/downstream processes to contribute to the success of GSK vaccine platforms based on both novel mRNA technology and conventional recombinant antigen.

This role will provide YOU the opportunity to lead key activities to progress YOUR career. These responsibilities include some of the following:

  • Support development / optimization / validation of a commercial manufacturing process for the purification of mRNA and recombinant protein antigen.
  • Independently design and execute laboratory experiments.
  • Partner with diverse team members from various functions, multiple countries and members at various levels in organization.
  • Benchmark specific technologies in own functional area to bring technology to state of the art.
  • Solve complex problems through analytical thinking to identify and understand alternatives using knowledge gained through formal education, experience and sound judgment.
  • Prepare oral and written reports to communicate scientific findings and to support project documentation and CMC submissions.
  • Comply with data integrity requirements for laboratory work.


Why you?

Basic Qualifications:

We are looking for professionals with these required skills to achieve our goals:
  • Degree in Biology, Biochemistry or Chemical Engineering or a related scientific field.
  • BSc with 5+ years of experience or MS with 3+ years of experience or PhD with 1+ years of experience.
  • Experience with different purification techniques such as chromatography and tangential flow filtration (TFF) and associated instrumentation such as Akta chromatography systems and Unicorn software.
  • Experience with bioanalytical assays associated with purification processes, such as SDS-PAGE, Western blotting, HPLC, etc.
  • Experience in research and development in a Biopharmaceutical industry or government laboratory setting is a must.
  • Understanding of experimental design and be able to independently execute laboratory experiments.


Preferred Qualifications:

If you have the following characteristics, it would be a plus:
  • Communicate effectively with regular verbal and formal updates to project teams and management.
  • Understanding of purification of biologics, specifically large size mRNA, including process scale-up.
  • Strong hands-on experience with a wide range of purification techniques for large nucleic acid molecules including affinity capture, ion exchange and hydrophobic interactions.
  • Experience and understanding of nucleic acid analytical technologies.
  • Understanding of Quality by Design and the development of a process control strategy.
  • Design and execute DOE studies & high-throughput screen for purification process improvements and advancements including parameter optimization, scale-up, process window determination and process capability evaluation.
  • Knowledge of technology transfer and GMP manufacturing.
  • Be able to rapidly acquire project understanding and apply professional knowledge to project improvement.
  • Demonstrated ability to efficiently work in a fast paced and fluid environment, changes in priority and timeline restrictions


Why GSK?

Our values and expectationsare at the heart of everything we do and form an important part of our culture.

These include Patient focus, Transparency, Respect, Integrity along with Courage, Accountability, Development, and Teamwork. As GSK focuses on our values and expectations and a culture of innovation, performance, and trust, the successful candidate will demonstrate the following capabilities:
  • Operating at pace and agile decision-making - using evidence and applying judgement to balance pace, rigour and risk.
  • Committed to delivering high quality results, overcoming challenges, focusing on what matters, execution.
  • Continuously looking for opportunities to learn, build skills and share learning.
  • Sustaining energy and well-being.
  • Building strong relationships and collaboration, honest and open conversations.
  • Budgeting and cost-consciousness.


*LI-GSK

*This is a job description to aide in the job posting, but does not include all job evaluation details.

If you require an accommodation or other assistance to apply for a job at GSK, please contact the GSK Service Centre at 1-877-694-7547 (US Toll Free) or +1 801 567 5155 (outside US).

GSK is an Equal Opportunity Employer and, in the US, we adhere to Affirmative Action principles. This ensures that all qualified applicants will receive equal consideration for employment without regard to race, color, national origin, religion, sex, pregnancy, marital status, sexual orientation, gender identity/expression, age, disability, genetic information, military service, covered/protected veteran status or any other federal, state or local protected class.

Important notice to Employment businesses/ Agencies

GSK does not accept referrals from employment businesses and/or employment agencies in respect of the vacancies posted on this site. All employment businesses/agencies are required to contact GSK's commercial and general procurement/human resources department to obtain prior written authorization before referring any candidates to GSK. The obtaining of prior written authorization is a condition precedent to any agreement (verbal or written) between the employment business/ agency and GSK. In the absence of such written authorization being obtained any actions undertaken by the employment business/agency shall be deemed to have been performed without the consent or contractual agreement of GSK. GSK shall therefore not be liable for any fees arising from such actions or any fees arising from any referrals by employment businesses/agencies in respect of the vacancies posted on this site.

Please note that if you are a US Licensed Healthcare Professional or Healthcare Professional as defined by the laws of the state issuing your license, GSK may be required to capture and report expenses GSK incurs, on your behalf, in the event you are afforded an interview for employment. This capture of applicable transfers of value is necessary to ensure GSK's compliance to all federal and state US Transparency requirements. For more information, please visit GSK's Transparency Reporting For the Record site.

Get job alerts

Create a job alert and receive personalized job recommendations straight to your inbox.

Create alert