Computational Biology - Institute Research Investigator

Location
Houston, Texas
Salary
Competitive
Posted
April 23 2021
Ref
139457
Organization Type
Healthcare/Hospital
The University of Texas MD Anderson Cancer Center aims to eliminate cancer in Texas, the nation, and the world, through outstanding programs that integrate patient care, research, and prevention, and through education for undergraduate and graduate students, trainees, professionals, employees, and the public.

MD Anderson Therapeutics Discovery Division
Within The University of Texas MD Anderson Cancer Center lies the Therapeutics Discovery Division (TDD), a powerful engine driving the future of new targeted, immune- and cell-based therapies. Therapeutics Discovery eliminates the bottlenecks that hamper traditional drug discovery by employing a multidisciplinary team of dedicated researchers, doctors, drug developers, and scientific experts working together to develop small-molecule drugs, biologics, and cellular therapies. Our unique structure and collaborative approach allow the team to work with agility, bringing novel medicines from concept to clinic quickly and efficiently - all under the same roof.

The TRACTION platform
The Translational Research to AdvanCe Therapeutics and Innovation in ONcology (TRACTION) platform is an industrialized translational research group that aligns world-class drug discovery and development with highly innovative the science and clinical care research, for which MD Anderson Cancer Center is known. Through an investment in patient-centric research, we have developed the infrastructure, platforms, and capabilities to enable transformative research. TRACTION's approach combines innovative cancer genetics, disruptive technologies, deep mechanistic biology, disease modeling, and pharmacology to accelerate the translation of novel discoveries into definitive clinical hypotheses. By partnering with the drug discovery engines within Therapeutics Discovery, we aim to advance a portfolio of small molecules, biologics, and cell therapies for our patients. We work in a fast-paced, milestone-driven environment with a focus on team science and interdisciplinary research. Our unique approach has created a biotech-like engine within the walls of the nation's leading cancer center to bring life-saving medicines to our patients more quickly and effectively.

We are seeking an a highly motivated and collaborative individual to join our team as an Institute Research Investigator (IRI) of Computational Biology. With strong expertise in computational biology, the Institute Research Investigator (IRI) be responsible for developing data analytics and data integration for team oriented projects that span early discovery to late stage translation, combining computational modeling with quantitative experimental data to understand complex biological systems and translate this understanding to the development of oncology therapeutics. These efforts will allow us to advance novel therapeutics currently under development by our Therapeutics Discovery teams and partners.
As a part of the Therapeutics Discovery team, you have the opportunity to use your talents to make a direct impact on the lives of our patients. Ideal candidates will have solid computer science and/or engineering/biostatistics obtained from an internship or work experience in addition to required education. Success will be measured by the ability to propose and execute computational biology workplans, integrating data from multiple molecular profiling platforms, and working closely with biologist to uncover biological and mechanistic insights, and to enable hypothesis-driven testing of oncology therapeutics and/or biomarker strategies in the clinical setting.

Key Functions

1. With minimal supervision, propose innovative solutions to research projects and contribute to project goals through computational biology and statistical data-analysis techniques.
2. Design, implement, and execute analytical strategies to inform on target discovery, target biology, mechanism of action, and biology of response for targets of interest.
3. Proactively drive development and application of cutting-edge analytics and methodologies to process and integrate data that leads to actionable hypothesis to support the objectives of the discovery and innovation, cancer biology, and translational biology teams.
4. Work closely with research teams to quantitatively interrogate hypotheses around tumor related genes/pathways to further advance scientific discovery and clinical therapeutic drug development.
5. Perform statistical analysis on biological datasets including parametric and non-parametric tests, data mining / machine learning algorithms.
6. Design, optimize and troubleshoot alternative computational techniques for new biology-based technologies and datasets in order to decipher complex biological systems and enable research team to meet program goals.
7. Develop and utilizes software for interrogation, visualization, and communication of multidimensional datasets to enable hypothesis generation and to gain insight into cancer biology.
8. Leverage oncogenomic datasets to identify targets, biomarkers of response, and develop clinical path hypothesis.
9. Interpret, present, and report research findings at internal meetings and external scientific conferences.

Education

Required: Bachelor's degree in biology, biochemistry, molecular biology, cell biology, enzymology, pharmacology, chemistry or related field.

Preferred: Ph.D. in Computer Science, Engineering, Applied Mathematics, Biostatistics or a related discipline from an accredited university

Experience

Required: Six years experience of relevant research experience in laboratory With Master's degree, four years of required experience. With a PhD in a natural science or Medical degree, no experience required.

Preferred Candidate will possess the following:

1. Strong foundation in both computer science concepts and molecular / cancer biology.
2. Evidence of proficiency in programing languages (Python, R), scripting languages (bash), high-performance computing, code version control, and computational notebook tools.
3. Experience with cloud computing, container images, reproducible workflows, and interactive visualization.
4. Experience with machine-learning and/or data mining algorithms (ie. Clustering, classification, etc.), and experience utilizing common parametric and non-parametric statistical tests (ie. T-test, ANOVA, Wilcoxon- signed-rank test, Fisher's exact test, etc.) for data analysis.
5. Evidence of ability to develop statistical algorithms, or the comprehensive assessment of algorithms, for the analysis of large multidimensional datasets of successfully manipulating large volume datasets and experience with high performance computing are essential
6. Knowledge and experience in areas of genomics, next-gen sequencing analytics (alignment tools, mutational variant callers, ChIP-seq, etc), pathway analysis, and network analysis.
7. Outstanding organizational skills and the ability to effectively present results and conclusions to co-workers, collaborators and manager.
8. Experience working with bench biologists, with examples where analytical methods enabled the validation of hypothesis.

It is the policy of The University of Texas MD Anderson Cancer Center to provide equal employment opportunity without regard to race, color, religion, age, national origin, sex, gender, sexual orientation, gender identity/expression, disability, protected veteran status, genetic information, or any other basis protected by institutional policy or by federal, state or local laws unless such distinction is required by law. http://www.mdanderson.org/about-us/legal-and-policy/legal-statements/eeo-affirmative-action.html

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