Post Doctoral Research Fellow - Next Generation Sequencing

Job Description:

The Rush University Alzheimer's Disease Center (RADC) is a leading experimental and epidemiological center for the study of Alzheimer's disease. Over the past decade, the RADC has carried out numerous community-based cohort studies and generated multi-omic data from human specimens (https://www.radc.rush.edu/). An ongoing effort is to expand our Next-Generation Sequencing (NGS) platform to discover molecular biomarkers and genetic drivers for early diagnosis and therapeutic interventions of Alzheimer's disease. As part of this major expansion, we are seeking a highly motivated Post doctoral Scientist in NGS and Molecular Genomics. This Scientist will lead our NGS effort in developing cutting-edge sequencing platform and single cell multi-omics technologies.

Job Responsibilities

• Develop new NGS and single cell omics capabilities and workflows

• Conduct day-to-day NGS experiments, problem solving and work prioritization

• Stay up to date with new technologies associated with NGS sample preparation, library construction and target capture

• Ability to independently troubleshoot, solve technical problems related to NGS assay design and execution

• Coordinate with other team members and communicate with PIs/outside collaborators to address their specific needs

• Run bioinformatics analysis and quality control for NGS datasets to ensure data quality

• Ability to calculate, graph and compile NGS data and present results in scientific meetings

• Train and mentor Research Assistants

• NGS capacity planning, billing and writing scientific reports

Job Requirements

• PhD or equivalent degree in the fields of Molecular biology, Genetics, Functional Genomics, Biochemistry, Bioinformatics, Neuroscience or related fields

• Extensive demonstrated experience in molecular biology and genetics/genomics including DNA/RNA isolation and manipulation, vector cloning, PCR, qPCR, NGS library prep, QC and sequencing.

• Experience with single cell multi-omics and 10X Genomics technologies

• Experience with high throughput operation of automated liquid handler

• Proficiency with CRISPR genome engineering is a plus

• Proficiency with bioinformatics software packages (such as R, Python and JMP) is a plus

• Demonstrated superior ability for experiment planning, execution and troubleshooting, and ability to develop/optimize new assays

• Demonstrated skills in organization, analysis and communication

• Proven ability to work independently and in collaborative team environments

Company Highlights:

• Ranked among the top academic medical centers in the country, Rush University Medical Center is an outstanding place to enhance your career. Everything we do centers on one goal: improving patient care.

• Rush University Medical Center received five stars in a quality rating system by the federal Centers for Medicare and Medicaid Services (CMS). Rush University Medical Center is the only five-star academic medical center in the Chicago area.

• As an academic medical center, Rush University Medical Center in Chicago, Illinois, is committed to advancing medical knowledge through research. Investigators at Rush are involved in more than 1,600 projects, including hundreds of clinical studies to test the effectiveness and safety of new therapies and medical devices, as well as to expand scientific and medical knowledge.

• RUMC offers a competitive salary, outstanding benefits & the professional advantages of an environment that supports your development & recognizes your achievements.

• Rush University is home to one of the first medical colleges in the Midwest and one of the nation's top-ranked nursing colleges, as well as graduate programs in allied health, health systems management and biomedical research.

Rush is an equal opportunity employer. We evaluate qualified applicants without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability, veteran status, and other legally protected characteristics.