Senior Scientist, Translational Research

Pfizer-Boulder (formerly Array BioPharma) is focused on the discovery, development and commercialization of targeted small molecule drugs to treat patients afflicted with cancer, and successfully launched approved drugs BRAFTOVI (encorafenib) and MEKTOVI (binimetinib) for the treatment of patients with BRAF mutated melanoma . These products have also been granted Breakthrough Therapy Designation by the FDA for BRAF mutated CRC.

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ROLE SUMMARY

The individual will support translational research programs to advance drug discovery and clinical development programs. They will leverage their expertise in molecular and cell biology, pharmacology, genomics and/or proteomics to lead and support research activities associated with translational studies to advance drug discovery and development programs. Areas of responsibility include drug resistance and sensitivity, mechanism of action and differentiation, biomarker discovery, and clinical biomarker strategy development and execution.

ROLE RESPONSIBILITIES

• Independently execute translational research to support advancement of drug discovery and clinical development programs
• Lead and conduct wet-lab molecular biology, cell biology and pharmacology studies to generate data that characterizes compound pharmacology and informs activity relating to drug resistance and sensitivity, mechanism of action and differentiation, biomarker discovery, and clinical biomarker strategy
• Contributes to development and/or implementation of new experimental capabilities with application to advance drug discovery and development programs
• Prepare and contribute to the preparation of high-quality written reports and oral presentations

BASIC QUALIFICATIONS

• PhD in biology, biochemistry, or related science plus at least 2-4 years' industry experience with a focus in Oncology.
• Knowledge and successful technical application of molecular biology, cell biology, pharmacology, genomics, and proteomics laboratory methods to advance oncology drug discovery, drug characterization and biomarker discovery.
• Technical expertise in culturing cell lines and primary cells
• Technical expertise in 2 or more of the following molecular and cell biology methods: analysis of protein expression by Western blot, immunofluorescence, flow cytometry, ELISA; analysis of gene expression by RT-PCR and RNA sequencing, and analysis of complex data sets
• Experience in small molecule drug discovery from lead identification to candidate nomination and IND submission
• Strong scientist who understands their role and responsibilities and works to contribute to the overall success of the teams and efforts they support
• Refined oral and written communication skills with the ability to effectively articulate key concepts
• Ability to work in a fast-paced environment with a high degree of independence to effectively address both strategic and tactical challenges, leveraging their strong understanding of biology, pharmacology, and oncology
• Recognized company wide as a subject matter and/or technical expert in one or more areas
• Candidate demonstrates a depth of experiences and capabilities including: the ability to conduct wet-lab studies and collaborate with peers to achieve meaningful outcomes and create business impact.

PHYSICAL/MENTAL REQUIREMENTS

• Lifting, sitting, standing, walking, bending, ability to perform mathematical calculations and ability to perform complex data analysis

NON-STANDARD WORK SCHEDULE, TRAVEL OR ENVIRONMENT REQUIREMENTS

• Able to adhere to safe work practices and perform lab works with appropriate personal protection equipment such as but not limited to safety goggles, facial mask, gloves, lab coat/ protective gowning, and closed toe shoes
• Able to work at flexible hours occasionally when performing time-sensitive experiments

OTHER JOB DETAILS

· Eligible for Employee Referral Bonus

· Eligible for Relocation Package

#LI-PFE

The annual base salary for this position ranges from $80,000 to $133,300. In addition, this position offers an annual bonus with a target of 12.5% of the base salary and eligibility to participate in our share based long term incentive program. Benefits offered include a retirement savings plan, paid vacation, holiday and personal days, paid caregiver/parental and medical leave, and health benefits to include medical, prescription drug, dental and vision coverage in accordance with the terms and conditions of the applicable plans.

Sunshine Act

Pfizer reports payments and other transfers of value to health care providers as required by federal and state transparency laws and implementing regulations. These laws and regulations require Pfizer to provide government agencies with information such as a health care provider's name, address and the type of payments or other value received, generally for public disclosure. Subject to further legal review and statutory or regulatory clarification, which Pfizer intends to pursue, reimbursement of recruiting expenses for licensed physicians may constitute a reportable transfer of value under the federal transparency law commonly known as the Sunshine Act. Therefore, if you are a licensed physician who incurs recruiting expenses as a result of interviewing with Pfizer that we pay or reimburse, your name, address and the amount of payments made currently will be reported to the government. If you have questions regarding this matter, please do not hesitate to contact your Talent Acquisition representative.

EEO & Employment Eligibility

Pfizer is committed to equal opportunity in the terms and conditions of employment for all employees and job applicants without regard to race, color, religion, sex, sexual orientation, age, gender identity or gender expression, national origin, disability or veteran status. Pfizer also complies with all applicable national, state and local laws governing nondiscrimination in employment as well as work authorization and employment eligibility verification requirements of the Immigration and Nationality Act and IRCA. Pfizer is an E-Verify employer.

Research and Development