Research Associate (Postdoctoral

Research Description: The Puglielli laboratory is recruiting a postdoctoral fellow with expertise in high-end microscopy, structural biology, and general biochemistry to study morphological changes of the endoplasmic reticulum (ER) and secretory pathway in cellular and mouse models of dysfunctional ER acetylation. This research is focused on the molecular mechanisms of different neurodevelopmental and neurodegenerative diseases. The laboratory is located at the Waisman Center of the University of Wisconsin-Madison and has access to cutting-edge research facilities. Madison, WI offers an outstanding living environment with cultural opportunities, excellent public schools, and many facilities for indoor and outdoor activities. Our research uses multidisciplinary approaches on in vitro, ex vivo and in vivo models.

Representative papers: Biochem J 2007, 407: 383-395; EMBO Rep 2008, 9: 916-922; J Biol Chem 2009, 284: 2482-2492; J Cell Sci 2010, 9: 174-190; J Biol Chem 2012, 287: 8424-8433; J Biol Chem 2012, 287: 29921-29930; Biochim Biophys Acta 2013, 1833: 686-697; J Biol Chem 2014, 289: 32044-32055; J Neurosci 2014, 34: 6772-6789; Brain 2016, 139: 937-952; J Exp Med 2016, 213: 1267-1284; Aging Cell 2019, 18:e13014; J Cell Sci 2018, 131:jcs221747; Nat Commun 2019; 10:3929; J Neurochem 2020; 154: 404-423. Sci Rep 2021; 11:2013; Commun Biol 2021; 4: 454.

Degree and area of specialization: PhD in relevant areas of biological sciences (neuroscience, biochemistry, cellular and molecular biology). MD candidates with strong commitment to basic science are also encouraged to apply.

Requirements: Applicants should have strong laboratory skills. Previous expertise in high-end microscopy and structural biochemistry is essential. Expertise with biochemistry and molecular biology techniques is also necessary. Applicants must be fluent in spoken and written English. The successful candidate will develop both independent and collaborative experiments in one or more areas.

Salary: Commensurate with experience

Begin and End Dates: Opening available immediately; 1 year initial appointment, renewable

Contact: Apply via email to Luigi Puglielli, MD, PhD (lp1@medicine.wisc.edu). E-mail your curriculum vitae, brief statement of interest and career goals, and contact names of at least three references.