Scientific Investigator - HBV

Collegeville, PA
March 01 2021
Organization Type
We are seeking a highly motivated Scientific Investigatorto work on new treatments to address the threat ofinfectious diseases by joining our growing Infectious Diseases Research Unit (RU) focused on Infectious Diseases at Upper Providence, PA. The Infectious Diseases Research Unit is one of the 4 Research Units in the R&D organization at GSK and is responsible for the discovery of novel approaches & targets to treat infectious diseases that threaten our health and progressing them to clinical proof of concept studies. The Research Unit has an impactful portfolio of projects in hepatitis B, bacterial infections and viral respiratory infections (including COVID-19) along with collaborations with Vir Biotechnology and 23&Me.

This position functions within Infectious Diseases Research Unit and supports target discovery through to candidate selection and early clinical development, along with nonclinical biology work for Phase 2 program for Hepatitis B virus (HBV). You would be responsible for conducting Infectious Disease related work in molecular and cell biology in the progression and advancement of drug discovery projects targeting HBV and other potential viral targets. Particular areas of focus will be in establishing complex in vitro models such as primary hepatocyte cell culture and other innovative approaches in the pursuit of a functional cure for HBV. The successful candidate will be science driven, familiar with most cell and molecular biology techniques and instrumentation, one who can assume personal accountability and keen to learn through experience to advance in their career.

Key accountabilities:
  • Establish and validate in vitro cellular models of HBV using primary human liver cell cultures and other cell types
  • Define, design, and perform experiments using in vitro cellular models to evaluate molecules and or genetic modifiers (e.g., CRISPR, siRNA) to validate drug discovery targets and/or progress lead optimization projects
  • Conduct pharmacological studies characterizing effects with an array of in vitro techniques that may include immunoassays (ELISA, MSD), TaqMan, high-content cell imaging, confocal microscopy, and RNAseq, among others
  • Independently execute laboratory experiments, conduct statistically supported data analysis, and deliver results in a timely manner to enable informed decision making
  • Contribute independently to the direction of the work, providing clear next steps for the research
  • Clearly communicate study results and impact in written form and at internal and external meetings.
  • Commit to continual improvement by reading and applying the latest scientific literature, methodologies and technologies.
  • Comply with all standards and practices of data integrity, ethics, and safety.
  • Model GSKs values of patient-focus, respect, transparency, and integrity
  • Define, design, and execute experiments

Why you?

Basic Qualifications:

We are looking for professionals with these required skills to achieve our goals:
  • Master of Science degree (virology or immunology) with 5 to 7 years of relevant research experience or a Bachelor's degree with 10 to 12 years of lab experience.
  • Experience working with primary cell cultures and technical experience with cellular/molecular biology and immunology assays (e.g. qRT-PCR, PCR, ELISA, RNA/DNA transfection, immunofluorescence, flow cytometry) and with handling of infectious agents.

Preferred Qualifications:

If you have the following characteristics, it would be a plus:
  • PhD with a 1 to 3 year post-doctoral fellowship in infectious disease area, preference for HBV
  • Understanding of drug discovery via previous experience in biotech/pharmaceutical projects
  • Previous experience in virus infection models and familiarity with the virus/host interaction landscape and immunology
  • Knowledge and experience in immunological assays to probe disease relevant mechanisms
  • Demonstrated productivity and impact through laboratory contributions to multiple projects
  • Outstanding written and oral communication skills
  • Ability to adapt to changing priorities
  • Strong work ethic with desire to carry out independent hypothesis generation and testing
  • The candidate must be a highly motivated self-starter, with excellent verbal and written communication skills, and the ability to work effectively individually and in team and matrix environments
  • Self-motivated and able to resolve technical challenges and deliver consistent results efficiently in a timely manner
  • Effective communication (both verbal and written) of scientific ideas and results to internal groups and program teams. Skills in interpreting results and drawing conclusions through independent working and with supervision
  • Demonstrated capability to address critical path biology activities of the research projects

Why GSK?

Our values and expectations are at the heart of everything we do and form an important part of our culture.

These include Patient focus, Transparency, Respect, Integrity along with Courage, Accountability, Development, and Teamwork. As GSK focuses on our values and expectations and a culture of innovation, performance, and trust, the successful candidate will demonstrate the following capabilities:

  • Operating at pace and agile decision-making - using evidence and applying judgement to balance pace, rigour and risk.
  • Committed to delivering high quality results, overcoming challenges, focusing on what matters, execution.
  • Continuously looking for opportunities to learn, build skills and share learning.
  • Sustaining energy and well-being
  • Building strong relationships and collaboration, honest and open conversations.
  • Budgeting and cost-consciousness


*This is a job description to aide in the job posting, but does not include all job evaluation details.

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