Pfizer

Senior Computational Biologist

Employer
Pfizer
Location
La Jolla, California
Salary
Competitive
Posted
April 06 2021
Ref
4810318
Position Type
Full Time
Organization Type
Pharma
Senior Computational Biologist

ROLE SUMMARY

We are looking for a highly motivated computational biologist with a strong biological and computational background to join a bioinformatic group to partner with an outstanding group of experimental scientists developing novel cancer vaccines and immuno-therapeutics. The successful candidate will work closely with immunologists and oncologists in a dynamic environment to advance the discovery and development of cancer vaccines and immunotherapies. This is an exciting opportunity to work with other bioinformatics group members working on tumor intrinsic mechanisms and collaborate in functional genomics, biophysics, proteomics, enzymology and structural biology. The successful candidate will also be responsible for analyzing biomarker data from early clinical development and applying innovative ways of translating these findings.

RESPONSIBILITIES

•Collaborate with bench scientists to design and execute computational analysis of high-throughput data from preclinical and clinical studies to support development of novel cancer vaccines and immunotherapies and contribute to data packages supporting decision making;

• Conduct in silico analysis to integrate, interpret, and mine internal and public data to address questions about neoantigen discovery, HLA typing, predictive biomarker, tumor indication, drug combination and resistance mechanisms;

• Actively participate in project teams with multidisciplinary backgrounds to formulate data-driven, actionable hypotheses;

• Devise and leverage state of the art computational approaches for cancer vaccines development and precision medicine;

• Develop tools for sharing and visualization of processed data.

QUALIFICATIONS

• PhD or equivalent in computational biology, bioinformatics, computer science, or related fields with 3+ years of post-degree experience or equivalent;

• Deep knowledge of vaccine development, immune oncology or immunology research and related tools/databases such as NetMHC and IEDB;

• Expertise in analysis of RNA structure and function and applications to RNA therapeutics;

• Proficiency in scientific programming languages (R/Maltab, Python) in UNIX/LINUX and experienced in high performance computing environment. Cloud computing experience is a plus;

• Experience processing and interpreting next generation sequencing data including WES and RNAseq

• Ability to multi-task, effectively communicate (oral and written) and work with diverse expertise project teams.

Other Job Details:
  • Last Date to Apply for Job: May 3, 2021
  • Eligible for Employee Referral Bonus: YES
  • Eligible for Relocation: YES


Sunshine Act

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EEO & Employment Eligibility

Pfizer is committed to equal opportunity in the terms and conditions of employment for all employees and job applicants without regard to race, color, religion, sex, sexual orientation, age, gender identity or gender expression, national origin, disability or veteran status. Pfizer also complies with all applicable national, state and local laws governing nondiscrimination in employment as well as work authorization and employment eligibility verification requirements of the Immigration and Nationality Act and IRCA. Pfizer is an E-Verify employer.

Research and Development

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