Senior Associate Scientist

Cambridge, Massachusetts
April 04 2021
Position Type
Full Time
Organization Type

Within the Internal Medicine Research Unit (IMRU), the Metabolism and Mass Spectrometry lab is focused on providing decision-making data in the identification / validation of new targets, and the development of new compounds for the treatment of metabolic diseases including cachexia, HFpEF, and NAFLD/NASH. We are seeking motivated self-aware individuals with excellent oral and written communication skills, and a deep interest in metabolism and biological sciences. The successful candidate will have skill sets in cellular and molecular biology, cell culture, analytical chemistry and liquid chromatography / mass spectrometry. The successful candidate will be able to learn new techniques quickly as needed to support projects. The candidate will be involved in research projects from early target validation to drug development and function in a team environment.

  • Conduct end-to-end analysis of pharmacodynamic markers from preclinical in vivo studies including metabolite extraction, standard curve generation, LCMS and data analysis.
  • Develop and validate in vitro assays to support portfolio projects.
  • Perform in vitro experiments to explore the mechanism of action of potential new targets and therapies.
  • Analysis of in vitro, ex vivo and in vivo samples to assess effect of target modulation, and to identify biomarkers of target engagement and efficacy.
  • Perform regular upkeep and troubleshoot LCMS instrumentation as needed, including (U)HPLCs, Sciex 5500, 6500, and Thermo Orbitraps.
  • Communicate and present data to project teams.
  • Maintenance of laboratory notebook records and adherence to safety policies is strictly required.

  • Bachelor's degree in Biology, Chemistry, or Biochemistry with 3+ years of lab experience.
  • Experience in applied LCMS, & general analytical chemistry techniques.
  • Wet lab experience with basic in vitro biology techniques.
  • Strong oral and written communication skills.
  • General knowledge of cellular metabolism.

  • Experience with Thermo or Bruker high resolution MS is preferred.

  • Lifting, sitting, bending, standing, walking

Other Job Details:
  • Last Date to Apply for Job: April 19, 2021
  • Eligible for Employee Referral Bonus: YES

Sunshine Act

Pfizer reports payments and other transfers of value to health care providers as required by federal and state transparency laws and implementing regulations. These laws and regulations require Pfizer to provide government agencies with information such as a health care provider's name, address and the type of payments or other value received, generally for public disclosure. Subject to further legal review and statutory or regulatory clarification, which Pfizer intends to pursue, reimbursement of recruiting expenses for licensed physicians may constitute a reportable transfer of value under the federal transparency law commonly known as the Sunshine Act. Therefore, if you are a licensed physician who incurs recruiting expenses as a result of interviewing with Pfizer that we pay or reimburse, your name, address and the amount of payments made currently will be reported to the government. If you have questions regarding this matter, please do not hesitate to contact your Talent Acquisition representative.

EEO & Employment Eligibility

Pfizer is committed to equal opportunity in the terms and conditions of employment for all employees and job applicants without regard to race, color, religion, sex, sexual orientation, age, gender identity or gender expression, national origin, disability or veteran status. Pfizer also complies with all applicable national, state and local laws governing nondiscrimination in employment as well as work authorization and employment eligibility verification requirements of the Immigration and Nationality Act and IRCA. Pfizer is an E-Verify employer.

Research and Development

Similar jobs

Similar jobs