Pfizer

Senior Associate Scientist

Employer
Pfizer
Location
Cambridge, Massachusetts
Salary
Competitive
Posted
April 04 2021
Ref
4806677
Position Type
Full Time
Organization Type
Pharma
ROLE SUMMARY

Within the Internal Medicine Research Unit (IMRU), the Metabolism and Mass Spectrometry lab is focused on providing decision-making data in the identification / validation of new targets, and the development of new compounds for the treatment of metabolic diseases including cachexia, HFpEF, and NAFLD/NASH. We are seeking motivated self-aware individuals with excellent oral and written communication skills, and a deep interest in metabolism and biological sciences. The successful candidate will have skill sets in cellular and molecular biology, cell culture, analytical chemistry and liquid chromatography / mass spectrometry. The successful candidate will be able to learn new techniques quickly as needed to support projects. The candidate will be involved in research projects from early target validation to drug development and function in a team environment.

ROLE RESPONSIBILITIES
  • Conduct end-to-end analysis of pharmacodynamic markers from preclinical in vivo studies including metabolite extraction, standard curve generation, LCMS and data analysis.
  • Develop and validate in vitro assays to support portfolio projects.
  • Perform in vitro experiments to explore the mechanism of action of potential new targets and therapies.
  • Analysis of in vitro, ex vivo and in vivo samples to assess effect of target modulation, and to identify biomarkers of target engagement and efficacy.
  • Perform regular upkeep and troubleshoot LCMS instrumentation as needed, including (U)HPLCs, Sciex 5500, 6500, and Thermo Orbitraps.
  • Communicate and present data to project teams.
  • Maintenance of laboratory notebook records and adherence to safety policies is strictly required.


BASIC QUALIFICATIONS
  • Bachelor's degree in Biology, Chemistry, or Biochemistry with 3+ years of lab experience.
  • Experience in applied LCMS, & general analytical chemistry techniques.
  • Wet lab experience with basic in vitro biology techniques.
  • Strong oral and written communication skills.
  • General knowledge of cellular metabolism.


PREFERRED QUALIFICATIONS
  • Experience with Thermo or Bruker high resolution MS is preferred.


PHYSICAL/MENTAL REQUIREMENTS
  • Lifting, sitting, bending, standing, walking


Other Job Details:
  • Last Date to Apply for Job: April 19, 2021
  • Eligible for Employee Referral Bonus: YES


Sunshine Act

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EEO & Employment Eligibility

Pfizer is committed to equal opportunity in the terms and conditions of employment for all employees and job applicants without regard to race, color, religion, sex, sexual orientation, age, gender identity or gender expression, national origin, disability or veteran status. Pfizer also complies with all applicable national, state and local laws governing nondiscrimination in employment as well as work authorization and employment eligibility verification requirements of the Immigration and Nationality Act and IRCA. Pfizer is an E-Verify employer.

Research and Development

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