Postdoctoral Fellow: Synaptic and Mitochondrial Mechanisms of Cognitive Decline, Dr. John Reynolds &

La Jolla, California
Commensurate with qualifications and in accordance with institutional and NIH federal guidelines.
March 26 2021
Position Type
Full Time
Organization Type


A funded postdoctoral position is available under the joint mentorship of Drs. Uri Manor and John Reynolds at the Salk Institute for Biological Studies.  The goal of the project is to understand how changes in synapses and peri-synaptic mitochondria contribute to age-related cognitive decline.  The project is motivated by the observation that the vast majority of the brain's energy budget supports the synapse, which is the seat of learning and memory.  The energetic needs of the synapse are met predominantly by mitochondria, which both support synaptic plasticity and are, themselves, plastic, altering their form, function and position to meet the changing needs of the synapse during learning and synaptic transmission.  The project is highly collaborative, drawing on complementary expertise in learning and memory, primate behavior, neurophysiology, synaptic function, live cell imaging and electron microscopy.  The trainee will gain expertise in all of these areas, allowing them to gain unprecedented insight into the mechanisms underlying age-related cognitive decline.  A doctoral degree in an area relevant to the project, such as neuroscience, biology or physics, and a demonstrated record of scientific excellence, as evidenced by first author publications in peer-reviewed scientific journals, are prerequisites for this position.  Expertise in slice physiology is desirable, though not required. 

To learn more about both labs here:


Ph.D. in Biological Sciences, Neurobiology, Physics or related fields.


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The contractor will not discharge or in any other manner discriminate against employees or applicants because they have inquired about, discussed, or disclosed their own pay or the pay of another employee or applicant. However, employees who have access to the compensation information of other employees or applicants as a part of their essential job functions cannot disclose the pay of other employees or applicants to individuals who do not otherwise have access to compensation information, unless the disclosure is (a) in response to a formal complaint or charge, (b) in furtherance of an investigation, proceeding, hearing, or action, including an investigation conducted by the employer, or (c) consistent with the contractor’s legal duty to furnish information. 


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