Postdoctoral researcher in 3D Genomic Technologies

Are you passionate about molecular methods and want to work in the exciting field of 3D Genome Biology?

A postdoc position in 3D Genomic Technologies is immediately available in the Bienko-Crosetto Lab(https://bienkocrosettolabs.org/) at Science for Life Laboratory (https://www.scilifelab.se/) and Karolinska Institute in Stockholm, Sweden.

We develop and apply cutting-edge microscopy (PMID: 30967549) and sequencing (PMID: 32451505) methods to study how chromatin is spatially organized in the nucleus, how this organization orchestrates gene expression programs, and how disruption of 3D chromatin architecture contributes to human disease.

You will combine cutting-edge next-generation sequencing and high-resolution microscopy technologies and lead the development of new methods for charting the spatio-temporal organization of chromatin in the cell nucleus.

You will be part of a dynamic and international research environment where you will work alongside scientists from very diverse fields and backgrounds, unlocking your creativity and ideas in unconventional ways.

Your mission

You will leverage on our lab’s vast expertise in both genomic (GPSeq, Nat Biotechnol 2020; CUTseq, Nat Comm 2019; BLISS, Nat Comm 2017; BLESS, Nat Meth 2013) and microscopy methods (iFISH, Nat Comm 2019; FuseFISH, Cell Rep 2014; HD-FISH, Nat Meth 2013), and unleash your creativity to engineer new methodologies for studying the spatial architecture of DNA, RNAs and proteins in the nucleus.

You will combine cutting-edge next-generation sequencing and high-resolution microscopy technologies, working in synergy with experts in computational methods and modeling approaches.

Our ultimate mission is to understand how the complex higher-order structure of chromatin in mammalian cells is established during the cell cycle, how it is dynamically reshaped during cell differentiation, and how it is rewired during carcinogenesis.

Your profile

Are you a curious, technology-driven and problem-solving-oriented individual? Are you passionate about laboratory work and developing new methods? Are you seeking to find solutions that can help tackle complex biological questions from unconventional angles?

You don’t need to know how to code or analyze complex datasets, but you will work in synergy with experts in bioinformatics and data science to tackle complex problems on a daily basis.

If you have previously worked in the field of 3D genome organization, that’s great! However, we also welcome applications from people from different fields, who have a solid expertise in molecular biology techniques and next-generation sequencing technologies.

Qualified to be employed as a postdoctor is one who has obtained a doctorate or has equivalent scientific competence. Applicants who have not completed a doctorate at the end of the application period may also apply, provided that all requirements for a completed degree are met before the (intended) date of employment. This must be substantiated by the applicant’s main supervisor, director or equivalent.

What we offer?

Karolinska Institutet is one of the world’s leading medical universities. Our vision is to pursue the development of knowledge about life and to promote better health for all. At Karolinska Institutet, we conduct innovative medical research and provide the largest range of biomedical education in Sweden. Karolinska Institutet is a state university, which entitles employees to several benefits such as extended holiday and a generous occupational pension. Employees also have free access to our modern gym and receive reimbursements for medical care.