Senior Research Associate

Location
Duarte, California
Salary
Competitive
Posted
March 21 2021
Ref
10009581-1
Position Type
Full Time
Organization Type
Healthcare/Hospital
Thank you for your interest. Please note, the purpose of this posting is to recruit for on-going and future positions in the T Cell Therapeutics Research Laboratory of Dr. Christine Brown.

About City of Hope
City of Hope, an innovative biomedical research, treatment and educational institution with over 6000 employees, is dedicated to the prevention and cure of cancer and other life-threatening diseases and guided by a compassionate, patient-centered philosophy.

Founded in 1913 and headquartered in Duarte, California, City of Hope is a remarkable non-profit institution, where compassion and advanced care go hand-in-hand with excellence in clinical and scientific research. City of Hope is a National Cancer Institute designated Comprehensive Cancer Center and a founding member of the National Comprehensive Cancer Network, an alliance of the nation's leading cancer centers that develops and institutes standards of care for cancer treatment.

Position Summary
We are currently looking for a senior research associate who will be a part of a translational science team for our CAR T cell clinical tria ls, https://www.cityofhope.org/car-t-cell-immunotherapy . Th e Senior Research Associate (SRA) position has a high degree of autonomy and typically consults with the PI, or designee, and other professional researchers on the scope, design and objectives of research projects; plans and directs the technical work of research associates, laboratory research assistants, technicians and aides.

Key Responsibilities include:
  • Interact and collaborate with a team of researchers focused on developing T cell therapies in a translational research environment across multiple malignancy types.
  • Conduct basic molecular biology techniques, including cloning, plasmid and genomic DNA purification, PCR, quantitative PCR, Western blot, transient and stable transfection of mammalian cell lines, QC and correlative study for clinical samples.
  • Develop new assays to interrogate correlative samples across multiple CAR T clinical trials.
  • Must have demonstrable computer skills in Microsoft Word, Excel, Microsoft Access, etc., as well as skills in data management and analyses.
  • This position also requires meticulous attention to detail and accuracy in lab work as well as accurate record keeping and lab documentation


Qualifications
Basic education, experience and skills required for consideration:
  • Bachelor's Degree in Biological Sciences or a related field required with a minimum of 8 years of laboratory experience in area of molecular biology; or Master's Degree in Biological Sciences or a related field preferred with a minimum of 6 years of laboratory experience in area of molecular biology.
  • The candidate will ideally have experience in the fields of immunology, immunotherapy and cancer biology, with demonstrated experience in CAR T design.
  • Experience in primer design, cloning, qPCR and westerns is required.
  • Experience in handling correlative samples and knowledge of GMP practices is highly preferred
  • Experience in virus packaging and transfection, multiparameter flow cytometry, immunohistochemistry and/or gene expression profiling and bioinformatics is preferred.
  • Ability to effectively lead a research team to successfully meet project goals.
  • Ability to collaborate with diverse group of scientists involved in the correlative studies.
  • Ability to design and execute laboratory experiments, critically interpret experimental results, and present data in a clear and concise manner.
  • Ability to participate in the preparation of grant applications and scientific publications.
  • Excellent oral and written communication skills.
  • A publication record in peer-reviewed scientific journals.

Additional Information:
See the Stephen Forman, M.D. web page for an overview of research interests at:
https://www.cityofhope.org/people/brown-christine ,
https://www.cityofhope.org/people/forman-stephen ,
https://www.cityofhope.org/research/car-t-cell-therapy .

City of Hope is committed to creating a diverse environment and is proud to be an equal opportunity employer. All qualified applicants will receive consideration for employment without regard to race, religion, color, national origin, sex, sexual orientation, gender identity, age, status as a protected veteran, or status as a qualified individual with disability.
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