Research Associate -Immunometabolism and Antibody Therapeutics

Location
Boston, Massachusetts (US)
Salary
$100,000+ per year and outstanding benefits; opportunity to be part of a thriving, collegial lab
Posted
March 11 2021
Position Type
Full Time
Organization Type
Academia
Job Type
Other

Laboratory of Gökhan S. Hotamışlıgil, Sabri Ülker Center

Department of Molecular Metabolism

Harvard TH Chan School of Public Health

Apply here: https://academicpositions.harvard.edu/postings/10152

This novel position will develop and manage a research program focusing on the area of immunometabolism, glucose and lipid metabolism, hormone action, and its interface with antibody therapeutics against metabolic disease. Key activities include, but are not limited to, working with other scientists in the group to identify, develop and implement sophisticated research methods to pursue the following questions:

  • Biochemical and biophysical studies for target protein characterization and physiological and pathophysiological roles in disease states
  • Supervise, coordinate and/or directly engage in mechanistic studies to characterize target action
  • Development of cellular assays and facilitate their HTP implementation in partner labs, coordinate CRO activities
  • Activities for functional validation of antibodies generated by partners, coordinate CRO activities, and efforts on identification of biomarkers, and patient stratification, Mendelian stratification, etc., for clinical transition.
  • Exploration of a large animal model in addition to mice to produce a scalable supply of endogenous protein and other studies

Additionally, this position will advise the PI in the development of research goals in this research area that could result in additional 3rd party relationships and in the eventual development of commercialization strategies. Evaluate project progress and advise the PI on alternative research strategies and methods to stimulate positive outcomes. Project management responsibilities for Ülker Center Strategic Alliance Research Portfolio include working with the Office of Technology Development to ensure that project milestones are achieved; reporting is provided to appropriate governance groups; manage interactions with research partners.

Requirements

Doctoral degree in biological sciences or a related field. Direct, and preferably industry, experience in antibody therapeutics and outstanding immunometabolic disease research in a collaborative academic/industrial research environment.  Experience in protein biochemistry, purification, structural work is also desired but not required.  Evidence of a high degree of accountability with regular interactions with multi-party collaborative projects, specifically academic/corporate research, regulatory bodies and record/data management. Demonstrated ability to think strategically to discern, develop, and maximize the value of potential research partnerships. Familiarity with patent development and filing procedures, handling inventions and discoveries, and regulations/requirements regarding intellectual property. Outstanding communication and management skills.

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