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Associate Director, Translational Oncology Lead

Employer
Pfizer
Location
La Jolla, California
Salary
Competitive
Closing date
Mar 16, 2021

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Discipline
Life Sciences, Oncology
Position Type
Full Time
Job Type
President/CEO/Director/VP
Organization Type
All Industry, Pharma
ROLE SUMMARY

As a core member of clinical project teams, this individual is responsible for developing and implementing a robust clinical oncology biomarker plan that translates our preclinical knowledge into competitive strategies for programs moving into early clinical development, and drives bench to bedside and bedside to bench learning.

ROLE RESPONSIBILITIES
  • For assigned projects of moderate complexity, develop scientifically rigorous clinical translational research strategies that identify the most attractive patient population and/or select patients for enrollment, determine Proof of Mechanism, establish early Signs of Efficacy, illuminate mechanisms of resistance, and drive combinations.
  • Analyze, interpret and report results of clinical biomarker analyses, including support of regulatory filings.
  • Partner collaboratively across integrated, multi-functional clinical teams encompassing development (e.g. clinical, clinical pharmacology, statistics, development operations) and research (e.g. close interactions with biologists and computational scientists), clinical biomarker assay specialists, diagnostics and asset leaders while participating in a culture of scientific excellence and innovation.
  • Engage drug discovery teams to ensure that preclinical data packages support clinical development plans.
  • Communicate and leverage findings across the organization to facilitate bedside to bench and bench to bedside learnings.
  • Assess state-of-the-art technologies, collaborate closely with computational and systems biologists, and academic collaborators to increase the impact of translational medicine on drug development.
  • Receives guidance from higher level colleagues on more complex projects; May seek guidance from the Head of Translational Oncology R&D for the most complex projects.


BASIC QUALIFICATIONS
  • Advanced degree (PhD, Pharm.D.) or equivalent experience, with a focus on cancer biology and a minimum of 5 years' experience in oncology drug discovery and/or development.
  • Candidates should possess a strong understanding of modern cancer biology, cancer genetics and/or immuno-oncology, with a documented focus on translational research and clinical biospecimen analysis in phase 1 clinical trials.
  • Demonstrated experience designing, executing and interpreting studies of cancer biomarkers in clinical trials, including biomarker development, validation and clinical application.
  • Ability to drive interactions at the interface between lab bench-based research and early clinical development up to proof of concept studies.
  • Direct experience or familiarity with state-of-the-art technologies applicable to cancer biomarker or immune response analysis such as next-generation sequencing, immunohistochemistry, immunofluorescence, flow cytometry, in situ hybridization, gene expression profiling, and digital image analysis.
  • Demonstrated ability to think strategically and creatively while contributing to projects, thrive in a highly collaborative, multi-disciplinary team setting; highly effective verbal and written communication skills.
  • Demonstrated ability to thrive in matrix organizations.
  • Candidate demonstrates a breadth of diverse leadership experiences and capabilities including: the ability to influence and collaborate with peers, develop and coach others, oversee and guide the work of other colleagues to achieve meaningful outcomes and create business impact.


PREFERRED QUALIFICATIONS
  • Experience with multiple modalities of anti-cancer therapeutics (e.g. small molecules, nanoparticles, antibodies, antibody-drug conjugates, bispecific antibodies, cancer vaccines).
  • Experience with both cell-autonomous and tumor microenvironment cancer biology mechanisms.
  • Experience leveraging genomic and molecular information from patients with extraordinary responses in early stage clinical trials to guide clinical development.
  • Familiarity with computational and statistical analysis tools such as scripting, Spotfire, JMP or R programming.
  • External scientific influence within the academic community, publication of primary research results in high-quality, peer-reviewed journals and national/international scientific reputation.


OTHER JOB DETAILS
  • Eligible for Employee Referral Bonus
  • Eligible for Relocation
  • #LI-PFE


Sunshine Act

Pfizer reports payments and other transfers of value to health care providers as required by federal and state transparency laws and implementing regulations. These laws and regulations require Pfizer to provide government agencies with information such as a health care provider's name, address and the type of payments or other value received, generally for public disclosure. Subject to further legal review and statutory or regulatory clarification, which Pfizer intends to pursue, reimbursement of recruiting expenses for licensed physicians may constitute a reportable transfer of value under the federal transparency law commonly known as the Sunshine Act. Therefore, if you are a licensed physician who incurs recruiting expenses as a result of interviewing with Pfizer that we pay or reimburse, your name, address and the amount of payments made currently will be reported to the government. If you have questions regarding this matter, please do not hesitate to contact your Talent Acquisition representative.

EEO & Employment Eligibility

Pfizer is committed to equal opportunity in the terms and conditions of employment for all employees and job applicants without regard to race, color, religion, sex, sexual orientation, age, gender identity or gender expression, national origin, disability or veteran status. Pfizer also complies with all applicable national, state and local laws governing nondiscrimination in employment as well as work authorization and employment eligibility verification requirements of the Immigration and Nationality Act and IRCA. Pfizer is an E-Verify employer.

Medical

#LI-PFE

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