Sr. Associate Scientist, Culture Process Development

Andover, Massachusetts
March 04 2021
Position Type
Full Time
Organization Type
Why Patients Need You

Pfizer's purpose is to deliver breakthroughs that change patients' lives. Research and Development is at the heart of fulfilling Pfizer's purpose as we work to translate advanced science and technologies into the therapies and vaccines that matter most. Whether you are in the discovery sciences, ensuring drug safety and efficacy or supporting clinical trials, you will apply cutting edge design and process development capabilities to accelerate and bring the best in class medicines to patients around the world.

What You Will Achieve

As a Senior Associate Scientist, you will be focused on developing robust, scalable, and high productivity cell culture processes for the manufacture of biological therapeutics for early- and late-phase clinical programs.

You will join an unusual team largely dedicated to making breakthroughs in bioreactor process intensification and applying those innovations to late-stage clinical programs with high material requirements, or other technical challenges. In some cases the scientist/engineer will work with pilot, clinical, or commercial-scale GMP facilities to demonstrate scalability of the novel processes. In some cases the scientist/engineer will collaborate with cell line development colleagues to evaluate genetically engineered cell lines with altered metabolic characteristics for attaining higher productivities and/or desired product quality in cell culture processes.

Your significant experience of applying knowledge of principles, concepts, and practices of the discipline will make you a critical member of the team. Your innovative scientific temperament will help Pfizer deliver new biopharmaceuticals to patients in need across the globe.

How You Will Achieve It
  • Design and execute cell culture experiments to optimize and enhance recombinant protein production using mammalian expression platforms.
  • Satisfactorily complete all Good Laboratory Practices and safety training in compliance with departmental requirements and follow appropriate safety practices in the workplace.
  • Assist in the tech transfer of manufacturing processes to pilot, clinical, and commercial facilities.
  • Design, plan and execute experiments in shake flasks, bench-top bioreactors, and other appropriate scale-down equipment.
  • Present data and strategy to scientists and management in appropriate internal and external venues (technical meetings, project team meetings, conferences) as appropriate.
  • Analyze and document experimental data generated, and ensure timely documentation in electronic laboratory notebooks and internal technical reports.
  • Evaluate data and provide clear reports that can be shared and transferred to and from cross-functional teams.


  • Bachelor's degree with 2-4 years' industrial experience or Master's degree with 0-2 years' industrial experience in the area of Chemical/Biochemical engineering, Cell Biology, Biochemistry, Microbiology, or related field.
  • Strong mammalian cell culture expertise required.
  • Strong trouble-shooting skills and extreme attention to detail required.
  • Excellent oral and written communication skills with experience in technical report writing.
  • Proficiency with using personal computers, Microsoft applications (including Word, Excel, PowerPoint, OneNote, etc.) and other relevant scientific software.

  • Knowledge pertaining to other heterologous expression systems desirable.
  • Experience with statistical tools and design of experiments (DOE).
  • Experience with small-scale cell culture/fermentation bioreactor/WAVE process development.
  • Knowledge of cell physiology/metabolism.
  • General knowledge of Good Laboratory Practices /Good Manufacturing Practices (also cGMP) practices.

  • Lifting small bioreactors (~10 lbs), sitting, standing, walking and bending.
  • Ability to perform mathematical calculations and ability to perform complex data analysis.

  • Majority of work will be standard business hours.
  • Some weekend work may occasionally be required.
  • Some travel may occasionally be required.
  • Most travel will be domestic, on rare occasions overseas.

Other Job Details:
  • Last Date to Apply for Job: March 24, 2021
  • Eligible for Employee Referral Bonus: YES


Sunshine Act

Pfizer reports payments and other transfers of value to health care providers as required by federal and state transparency laws and implementing regulations. These laws and regulations require Pfizer to provide government agencies with information such as a health care provider's name, address and the type of payments or other value received, generally for public disclosure. Subject to further legal review and statutory or regulatory clarification, which Pfizer intends to pursue, reimbursement of recruiting expenses for licensed physicians may constitute a reportable transfer of value under the federal transparency law commonly known as the Sunshine Act. Therefore, if you are a licensed physician who incurs recruiting expenses as a result of interviewing with Pfizer that we pay or reimburse, your name, address and the amount of payments made currently will be reported to the government. If you have questions regarding this matter, please do not hesitate to contact your Talent Acquisition representative.

EEO & Employment Eligibility

Pfizer is committed to equal opportunity in the terms and conditions of employment for all employees and job applicants without regard to race, color, religion, sex, sexual orientation, age, gender identity or gender expression, national origin, disability or veteran status. Pfizer also complies with all applicable national, state and local laws governing nondiscrimination in employment as well as work authorization and employment eligibility verification requirements of the Immigration and Nationality Act and IRCA. Pfizer is an E-Verify employer.

Research and Development


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