Postdoctoral Associates - Structural Biophysics
Multiple postdoctoral positions are available for highly motivated candidates in the Levinson Laboratory in the Department of Pharmacology at the University of Minnesota, Twin Cities campus. The Levinson Lab studies allostery and drug recognition in protein kinases using advanced biophysical spectroscopy coupled with structural and biochemical methods. A core focus of the lab is understanding the allosteric basis for how drug binding to the active site modulates kinase protein-protein interactions in cancer. Our projects are performed in close collaboration with the lab of David D. Thomas in the Department of Biochemistry, Molecular Biology, and Biophysics, whose time-resolved fluorescence methodology for tracking protein conformational changes is a core component of our experimental toolkit. Successful applicants will work in a highly collaborative environment that spans the disciplines of structural biology, biophysics, and biochemistry and will be exposed to a wealth of techniques from X-ray crystallography to optical spectroscopy and magnetic resonance.
Available projects include:
1) real-time tracking of ligand-driven allosteric structural transitions in kinases using time-resolved FRET and NMR
2) dissection of oncogenic kinase scaffolding interactions using X-ray crystallography, cryo-EM, NMR, EPR and FRET
3) allosteric drug discovery using a novel high-throughput screening platform based on nanosecond time-resolved FRET
Example recent papers:
Majumdar et al., Nat Chem Biol (2021)
Lake et al., PNAS (2018)
Ruff et al., eLife (2018)
Cyphers et al., Nat Chem Biol (2017)
- PhD in biophysics, biochemistry, or a related field
- Strong communication and interpersonal skills
- Aptitude for working in a collaborative team
- Experience with recombinant protein expression, particularly in insect cells and/or mammalian cells.
- Familiarity with biomolecular spectroscopy, including fluorescence, infrared spectroscopy, and magnetic resonance
How to Apply:
Candidates should send a CV and cover letter to Dr. Nicholas Levinson (email@example.com) along with contact information for 3 references
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About the U of M
The University of Minnesota, Twin Cities (UMTC), is among the largest public research universities in the country, offering undergraduate, graduate, and professional students a multitude of opportunities for study and research. Located at the heart of one of the nation's most vibrant, diverse metropolitan communities, students on the campuses in Minneapolis and St. Paul benefit from extensive partnerships with world-renowned health centers, international corporations, government agencies, and arts, nonprofit, and public service organizations.