Postdoc in Spatial Omics

New Haven, Connecticut (US)
February 27 2021
Position Type
Full Time
Organization Type

Siyuan (Steven) Wang’s lab at Yale is seeking multiple highly motivated postdoctoral research fellows interested in the rapidly expanding field of spatial genomics, spatial multi-omics, and 4D nucleome.

Research in our lab focuses on the development and application of state-of-the-art imaging-based omics approaches to understand the spatial organization of mammalian genome and transcriptome, and how they impact cellular states. Recent advances include the development of the first-in-kind image-based 3D genomics method termed chromatin tracing to trace the spatial folding of genome, co-development of MERFISH for spatial transcriptome profiling (See Nature Methods Method of the Year 2020:, and the development of MINA to measure multiscale chromatin folding, copy numbers of numerous RNA species, and associations of numerous genomic regions with nuclear landmarks in the same, single cells in mammalian tissue (Science 2016, Science 2015, Molecular Cell, 2020, Nature Communications 2020, Trends in Cell Biology 2020, Nature Protocols in press). As one of the leading labs in this field, we are well funded with $9M through four NIH mechanisms received in 2019-2020. We have established a very dynamic and productive lab culture ( despite the previous small size of the lab.

The postdoctoral fellows will actively engage in developing the next generation of image-based omics technologies and/or the application of these technologies to different biomedical investigations. Individuals with expertise in any one of the following areas are strongly encouraged to apply: 1) sequencing-based omics technology development; 2) light microscopy and optical instrumentation; 3) molecular and cellular biology with mammalian/clinical cell culture or tissue especially in cancer.

We expect successful candidates to have strong academic background and publication record, at the level of being able to compete in postdoctoral fellowship competitions in the US, although participation/success in fellowship competition is not required for the renewal of the appointment.

The position is renewable annually, with immediate start availability.

To apply, please send your CV and cover letter with a description of previous research, and have three letters of recommendation sent to