Senior Associate Scientist In Vitro Pharmacology

Cambridge, Massachusetts
February 26 2021
Position Type
Full Time
Organization Type

The Internal Medicine Research Unit (IMRU) is seeking a highly motivated laboratory scientist to be a member of the in vitro pharmacology/assay development group. This Senior Associate Scientist will be an integral member of a team which broadly supports the IMRU portfolio across all the disease areas of interest. The individual will apply a scientific background in in vitro pharmacology to develop primary assays for carrying out SAR (structure-activity relationships) and design/execute experiments for understanding the mechanism of action of compounds throughout different stages of the project. In this position, the successful candidate will work within a large matrix environment, across a portfolio of programs, collaborating with multiple groups including discovery biology and several partner lines including medicinal chemistry and the central primary pharmacology group.

  • Perform laboratory experiments to establish robust biochemical and cell-based compound screening assays across a broad array of target classes for metabolism project teams.
  • Maintain immortalized cell, primary cell and iPS cell cultures as needed for assay development and low volume screening efforts.
  • Collaborate with the Primary Pharmacology Group to ensure alignment around assay technology selection, assay quality criteria and validation requirements.
  • Operate a broad array of liquid-handling and plate-based pharmacology equipment to ensure efficient automated workflows for newly developed assays.
  • Ensure efficient assay transfer to Primary Pharmacology Group or external screening vendors.
  • Prepare and present experimental results to project teams.
  • Maintain high quality experimental records within electronic laboratory notebook.

  • BA, BS or Masters in biology, pharmacology, biochemistry or a related field with 3 years of laboratory experience relevant to this position.
  • Broad understanding of biology, preferably with an emphasis in neuroscience and/or metabolism.
  • Scientific understanding of the major target classes (GPCRs, enzymes, transporters, ion channels, etc.).
  • Experience with assay development methodologies.
  • Experience with cell culture (primary and immortalized).
  • Experience in low to moderate throughput compound screening preferred but not mandatory.
  • Experience with automation of liquid handling and screening workflows preferred but not mandatory.
  • Ability to conduct data analysis using Microsoft Excel, GraphPad Prism, or equivalent software.
  • Ability to complete experiments and present results in individual and group settings.
  • Ability to work on multiple programs simultaneously and be an integral member of cross-functional project teams.
  • Proven verbal and written communication skills, and the ability to work in a collaborative team environment.

Other Job Details:
  • Last Date to Apply for Job: March 29, 2021
  • Eligible for Employee Referral Bonus: YES


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Research and Development

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