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Senior Associate Scientist In Vitro Pharmacology

Employer
Pfizer
Location
Cambridge, Massachusetts
Salary
Competitive
Closing date
Mar 5, 2021

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ROLE SUMMARY

The Internal Medicine Research Unit (IMRU) is seeking a highly motivated laboratory scientist to be a member of the in vitro pharmacology/assay development group. This Senior Associate Scientist will be an integral member of a team which broadly supports the IMRU portfolio across all the disease areas of interest. The individual will apply a scientific background in in vitro pharmacology to develop primary assays for carrying out SAR (structure-activity relationships) and design/execute experiments for understanding the mechanism of action of compounds throughout different stages of the project. In this position, the successful candidate will work within a large matrix environment, across a portfolio of programs, collaborating with multiple groups including discovery biology and several partner lines including medicinal chemistry and the central primary pharmacology group.

ROLE RESPONSIBILITIES
  • Perform laboratory experiments to establish robust biochemical and cell-based compound screening assays across a broad array of target classes for metabolism project teams.
  • Maintain immortalized cell, primary cell and iPS cell cultures as needed for assay development and low volume screening efforts.
  • Collaborate with the Primary Pharmacology Group to ensure alignment around assay technology selection, assay quality criteria and validation requirements.
  • Operate a broad array of liquid-handling and plate-based pharmacology equipment to ensure efficient automated workflows for newly developed assays.
  • Ensure efficient assay transfer to Primary Pharmacology Group or external screening vendors.
  • Prepare and present experimental results to project teams.
  • Maintain high quality experimental records within electronic laboratory notebook.


QUALIFICATIONS
  • BA, BS or Masters in biology, pharmacology, biochemistry or a related field with 3 years of laboratory experience relevant to this position.
  • Broad understanding of biology, preferably with an emphasis in neuroscience and/or metabolism.
  • Scientific understanding of the major target classes (GPCRs, enzymes, transporters, ion channels, etc.).
  • Experience with assay development methodologies.
  • Experience with cell culture (primary and immortalized).
  • Experience in low to moderate throughput compound screening preferred but not mandatory.
  • Experience with automation of liquid handling and screening workflows preferred but not mandatory.
  • Ability to conduct data analysis using Microsoft Excel, GraphPad Prism, or equivalent software.
  • Ability to complete experiments and present results in individual and group settings.
  • Ability to work on multiple programs simultaneously and be an integral member of cross-functional project teams.
  • Proven verbal and written communication skills, and the ability to work in a collaborative team environment.


Other Job Details:
  • Last Date to Apply for Job: March 29, 2021
  • Eligible for Employee Referral Bonus: YES


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EEO & Employment Eligibility

Pfizer is committed to equal opportunity in the terms and conditions of employment for all employees and job applicants without regard to race, color, religion, sex, sexual orientation, age, gender identity or gender expression, national origin, disability or veteran status. Pfizer also complies with all applicable national, state and local laws governing nondiscrimination in employment as well as work authorization and employment eligibility verification requirements of the Immigration and Nationality Act and IRCA. Pfizer is an E-Verify employer.

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