Postdoctoral Research Fellow

Postdoctoral Position in Genome Stability Maintenance

The Sobeck Lab is seeking a post-doctoral researcher to work in areas of genome stability maintenance. The NIH-funded research project (R01GM132596) focuses on roles of the Fanconi Anemia (FA) pathway in the context of chromatin structure regulation. The successful candidate will utilize human cell models in combination with molecular biology and biochemistry methods to functionally dissect crosstalk mechanisms between the FA pathway and chromatin remodelers during DNA replication.

Qualifications: A Ph.D. in biochemistry, molecular and cellular biology or related areas is required. Candidates with strong expertise in DNA replication & repair, chromatin biology or gene expression control will be considered.  Salary will be according to NIH guidelines (NOT-OD-20-070).

Research in the Sobeck lab (https://cbs.umn.edu/contacts/alexandra-sobeck) focuses on understanding how genomic maintenance networks regulate DNA replication and repair. We recently identified several histone chaperones and chromatin remodeling factors as novel functional FA pathway interactors and are setting out to determine the functional significance and underlying mechanisms of these interactions. Answering these questions will impact our understanding of genome maintenance and can aid future treatment strategies for Fanconi Anemia and related cancer predisposition syndromes.

The Department of Biochemistry, Molecular Biology & Biophysics (https://med.umn.edu/bmbb) has over 50 faculty members with very diverse research programs. The University of Minnesota provides an intellectually very stimulating environment that is ranked among the top 30 institutions in NIH-sponsored research. The University houses a NIC-designated center for cancer research (Masonic Cancer Center) and has excellent core facilities including the Genome Engineering Shared Resource (GESR), the Genomics Center (UMGC), the Minnesota Supercomputing Institute (MSI), the Flow Cytometry Resource and the Imaging Center.

The University is committed to promote a diversity of views, experiences, and ideas in the pursuit of research, scholarship, and creative excellence, and we encourage candidates from underrepresented backgrounds to apply. To learn more about diversity at the U: http://diversity.umn.edu

If interested, please reach out to Dr. Sobeck (asobeck@umn.edu) with a cover letter describing your interest in genome stability research and your suitability for this position, your CV and the names/info for three references.