Senior Scientist, Immunotherapeutic Design

La Jolla, California
February 22 2021
Position Type
Full Time
Organization Type
Job Type
Senior Scientist

The Cancer Immunology Discovery (CID) group in La Jolla, CA is focused on the generation of large molecule immuno-therapeutics that promote anti-tumor activity or counter immunosuppression in the tumor microenvironment. Protein engineering efforts are supported by a world class antibody generation program, and a commitment to effective biotherapeutic design that stresses both ingenuity and simplicity. Our team takes a holistic approach to understanding the interplay of tumor, stromal, and immune cells in the tumor microenvironment, striving to define the axis of intercellular communication that could be leveraged to generate novel therapeutics.

We are seeking a qualified candidate to join us at a Senior Scientist level within Immunotherapeutic Design to contribute to protein sciences activities for the identification of novel biotherapeutics. The successful candidate will work closely with individuals in T Cell Activation and PDx Resistance, Immunosuppression, Tumor Immunogenicity, and BioMedicine Design groups to innovate and develop the next generation of protein therapeutics for immunotherapy.

  • Carry out hands-on lab work to apply molecular biology, protein engineering, and protein chemistry techniques to generate novel protein therapeutics to target the immune system.
  • Participate and present in internal and external project meetings as well as at site and cross-site meetings.
  • Communicate experimental findings accurately and concisely in both oral and written formats.
  • Deliver novel drug development opportunities through the rapid incorporation of emerging biotechnologies to ensure our team continues research on the leading-edge of oncology drug discovery.

  • PhD in Biochemistry, Molecular Biology, or related discipline or MS with 8+ years' relevant post-graduate experience.
  • Technical expertise should include protein expression, purification, and characterization.
  • Experience using structural and biophysical tools for protein design and lead prioritization.
  • Ability to independently design, plan, and interpret experiments.

  • Strong track record of scientific accomplishments demonstrated through publications in highly regarded journals and/or intellectual property generation.
  • Track record of demonstrating analytical skills, creativity, and unique problem solving skills.
  • Technical expertise with instruments such as Cytiva AKTA Pure/Avant, Agilent HPLC, Perkin-Elmer LabChip, Unchained Labs Uncle, and Cytiva Biacore T200/8K.
  • Prior experience in working with immune system derived proteins like antibody, TCR, cytokine, and antibody-like scaffold proteins is preferred.
  • Protein modeling and analyzing protein structures is preferred.
  • Liquid handler programming and high throughput purification is a plus.

  • Must have strong interpersonal skills, and a desire to work in collaboration.

  • There will be less than 5% travel

  • Eligible for Relocation Package
  • Eligible for Employee Referral Bonus


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Research and Development


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