3D Cell Culture Model

Rockville, MD
December 08 2020
Organization Type
Are you energized by a challenging role in biology, where scientific demand is driving team growth? If so, this Scientist role would be a great opportunity to consider.

The Molecular Biology and Systems Serology (MBSS) function at the GSK Slaoui Center for Vaccines Research, is responsible for the application of molecular biology and microbiology to identify antigen compositions, enabling of vector platforms for vaccine delivery, application of cell biology and systems serology to define vaccine potency and mechanism of action, and establishment of molecular biology technical capacity for vaccine development. Within MBSS the mission of the Laboratory of Molecular Analytics is to provide assay and analytical support to all vaccine projects in the US Research and Development Center, using advanced high-throughput technology and techniques.

We are looking for a highly motivated scientist, with proven 3D in vitro tissue modeling laboratory experience, to join our diverse preclinical research and development team working on RNA vaccines.

This role will provide YOU the opportunity to lead key activities to progress YOUR career. These responsibilities include some of the following:
  • Design, develop, and implement protocols of 3D in vitro tissue models (organoids, organs on a chip, bio-printed tissues, etc.) of interest for vaccine research and development.
  • Conduct studies that provide understanding of the mechanism of action of mRNA vaccines, through expression of encoded antigens in relevant tissues.
  • Investigate innate and adaptive immunity elicited by vaccines in in vitro models.
  • Run wide range of experiments/technical studies/tasks, for evaluation of 3D models using different molecular and microscopy techniques.
  • Analyze, interpret and record experimental results and presents them in written/oral communications.
  • Work cross-functionally across GSK Vaccines and Pharma network to coordinate and execute studies by collaborating with scientists throughout the organization to support development of 3D models.
  • Cultivate extramural activities with collaborators from academic and research organizations
  • Develop and execute new methods and protocols and proactively incorporate new technology or techniques into practice with minimal supervision.
  • Perform complex data management tasks to deliver data that informs vaccine research activities with scientific independence and minimal supervision.
  • Lead and support vaccine development-related scientific investigations and publishes the work in scientific journals and patent filings.

Why you?

Basic Qualifications:

We are looking for professionals with these required skills to achieve our goals:
  • PhD in Biological Sciences/Biomedical Engineering with 0+ years of experience OR Master's Degree with 3+ years laboratory experience OR Bachelors with 5+ years of laboratory experience working in pharmaceutical/biotechnology industry, academic or government institutions.
  • Hands-on experience with 3D models and bioimaging (confocal microscopy, in situ hybridization).

Preferred Qualifications:

if you have the following characteristics, it would be a plus:
  • Familiarity with molecular biology of innate and adaptive immune responses
  • Strong scientific track record of published scientific contribution
  • Excellent written and oral communication skills as well as presentation skills.
  • Must be detail oriented; possess problem solving skills and the ability to handle multiple tasks.
  • Demonstrate a detailed knowledge of Cellular and Molecular Biology, Histology, and Imaging theory.
  • Able to efficiently manage uncertainty, changes in priority and timeline restrictions.

Why GSK?

Our values and expectationsare at the heart of everything we do and form an important part of our culture.

These include Patient focus, Transparency, Respect, Integrity along with Courage, Accountability, Development, and Teamwork. As GSK focuses on our values and expectations and a culture of innovation, performance, and trust, the successful candidate will demonstrate the following capabilities:
  • Operating at pace and agile decision-making - using evidence and applying judgement to balance pace, rigour and risk.
  • Committed to delivering high quality results, overcoming challenges, focusing on what matters, execution.
  • Continuously looking for opportunities to learn, build skills and share learning.
  • Sustaining energy and well-being.
  • Building strong relationships and collaboration, honest and open conversations.
  • Budgeting and cost-consciousness.

*This is a job description to aide in the job posting, but does not include all job evaluation details.

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GSK is an Equal Opportunity Employer and, in the US, we adhere to Affirmative Action principles. This ensures that all qualified applicants will receive equal consideration for employment without regard to race, color, national origin, religion, sex, pregnancy, marital status, sexual orientation, gender identity/expression, age, disability, genetic information, military service, covered/protected veteran status or any other federal, state or local protected class.

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