Senior Scientist, Protein Biochemistry

Collegeville, PA
January 07 2021
Organization Type
Job Type
Senior Scientist
GlaxoSmithKline is a world leading research-based pharmaceutical company that combines both individual talent & technical resources to create a platform for the delivery of strong growth in a rapidly changing healthcare market. Our mission is to improve the quality of human life by enabling people to do more, feel better, & live longer. There are multiple exciting opportunities in the GlaxoSmithKline Synthetic Biochemistry and Protein Reagents groups. The primary focus of this role is to support the delivery of novel protein reagents for early phase drug discovery, as well as the continued development of a high throughput protein expression and reagent discovery platform. The successful candidate would participate on an interdisciplinary team tasked with providing early target assessment and reagent delivery into the GSK discovery portfolio.

Success in GSK thrives on strong interpersonal skills combined with a curious, inquisitive nature and a passion for science.You are equally passionate about developing yourself, developing new scientific methodologies, pushing the limits of innovation, and learning something new every day. You are an excellent team player, able to work with others either in the lab or in the office as well as within cross-functional teams. You are independent and able to plan and execute your own workload and deliver results. Your science is conducted with integrity, safety, and the highest standards.

This role will provide YOU the opportunity to lead key activities to progress YOUR career. These responsibilities include some of the following:
  • Collaboratively contribute to biologically relevant target construct design and assessment strategies
  • Implement appropriate assays for screening protein expression and quality in high throughput
  • When appropriate, support scale up and purification of protein constructs
  • Generate protein variants for high throughput characterization
  • Manipulate large-scale datasets using MS Excel and equipment interfacing programs.
  • Liaise with scientists & external collaborators at all levels
  • Generate conclusion reports, present data in team meetings & participate in writing of abstracts & publications
  • Conduct scientific work programs and make contributions both independently and as a member of a team with other R&D staff
  • Work through problems logically and apply innovative solutions (appropriate to grade)
  • Adopt new technologies and apply them to project work
  • Maintain customer focus, motivate self, and demonstrate a high degree of urgency
  • Use scientific literature and database resources in the execution of project related work
  • Exhibit flexibility, being open to new ways of working

Why you?

Basic Qualifications:

We are looking for professionals with these required skills to achieve our goals:
  • B.S. in Biochemistry, Biotechnology, Molecular Biology, Chemical Biology, or related field with 1-2 years relevant lab-based experience
  • Experience in the expression and characterization of protein constructs using E. coli host systems
  • Experience with common protein analysis tools, including SDS-PAGE and immunoassays.
  • Experience in molecular cloning techniques, including PCR, Sanger sequencing and cellular transformation

Preferred Qualifications:

If you have the following characteristics, it would be a plus:
  • M.S. in Biochemistry, Synthetic Biology, Biomolecular Engineering, Molecular Biology, Chemical Biology, or related field with 2-5 years relevant experience.
  • Experience with parallel experimentation, high throughput assay development, Design of Experiments, etc.
  • Experience with a variety of protein expression platforms, including E. coli , Insect cell culture and mammalian expression systems
  • Experience with a variety of protein purification techniques, including ion exchange chromatography, size exclusion chromatography and affinity chromatography
  • Significant hands-on experience with construct design and generation of protein constructs
  • Familiarity with or interest in learning automation equipment.
  • Demonstrated ability to work in multi-disciplinary teams, displaying excellent interpersonal, organizational, and communication skills


Why GSK?

Our values and expectationsare at the heart of everything we do and form an important part of our culture. These include Patient focus, Transparency, Respect, Integrity along with Courage, Accountability, Development, and Teamwork. As GSK focuses on our values and expectations and a culture of innovation, performance, and trust, the successful candidate will demonstrate the following capabilities:
  • Operating at pace and agile decision-making - using evidence and applying judgement to balance pace, rigour and risk.
  • Committed to delivering high quality results, overcoming challenges, focusing on what matters, execution.
  • Continuously looking for opportunities to learn, build skills and share learning.
  • Sustaining energy and well-being.
  • Building strong relationships and collaboration, honest and open conversations.
  • Budgeting and cost-consciousness.


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GSK is an Equal Opportunity Employer and, in the US, we adhere to Affirmative Action principles. This ensures that all qualified applicants will receive equal consideration for employment without regard to race, color, national origin, religion, sex, pregnancy, marital status, sexual orientation, gender identity/expression, age, disability, genetic information, military service, covered/protected veteran status or any other federal, state or local protected class.

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