Principal Scientist, AAV Production
- Employer
- Pfizer
- Location
- Cambridge, Massachusetts
- Salary
- Competitive
- Closing date
- Feb 28, 2021
View more
- Discipline
- Health Sciences, Drug Development, Other, Manufacturing/QA/QC
- Position Type
- Full Time
- Organization Type
- All Industry, Pharma
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ROLE SUMMARY
We are seeking a creative and driven senior candidate to lead development of AAV production platform in the BioMedicine Design (BMD) line of the Medicinal Sciences Organization. The candidate will capitalize on their AAV production experience to optimize processes for the advancement of AAV expression platform in the discovery space to support the gene therapy portfolio across Pfizer.
ROLE RESPONSIBILITIES
BASIC QUALIFICATIONS
PREFERRED QUALIFICATIONS
Other Job Details:
#LI-PFE
Sunshine Act
Pfizer reports payments and other transfers of value to health care providers as required by federal and state transparency laws and implementing regulations. These laws and regulations require Pfizer to provide government agencies with information such as a health care provider's name, address and the type of payments or other value received, generally for public disclosure. Subject to further legal review and statutory or regulatory clarification, which Pfizer intends to pursue, reimbursement of recruiting expenses for licensed physicians may constitute a reportable transfer of value under the federal transparency law commonly known as the Sunshine Act. Therefore, if you are a licensed physician who incurs recruiting expenses as a result of interviewing with Pfizer that we pay or reimburse, your name, address and the amount of payments made currently will be reported to the government. If you have questions regarding this matter, please do not hesitate to contact your Talent Acquisition representative.
EEO & Employment Eligibility
Pfizer is committed to equal opportunity in the terms and conditions of employment for all employees and job applicants without regard to race, color, religion, sex, sexual orientation, age, gender identity or gender expression, national origin, disability or veteran status. Pfizer also complies with all applicable national, state and local laws governing nondiscrimination in employment as well as work authorization and employment eligibility verification requirements of the Immigration and Nationality Act and IRCA. Pfizer is an E-Verify employer.
Research and Development
#LI-PFE
We are seeking a creative and driven senior candidate to lead development of AAV production platform in the BioMedicine Design (BMD) line of the Medicinal Sciences Organization. The candidate will capitalize on their AAV production experience to optimize processes for the advancement of AAV expression platform in the discovery space to support the gene therapy portfolio across Pfizer.
ROLE RESPONSIBILITIES
- Lead development of purification platform for novel AAV capsids.
- Oversee and support all aspects of AAV production at various scales (including generating high quality material for NHP studies).
- Collaborate with groups across Pfizer to develop processes compatible with and capitalizing on existing internal knowledge/infrastructure.
- Routinely generate top quality data packages and present at project meetings.
- Propose experimental designs and work closely with cross-functional teams, project leads and senior group members on identifying/advancing best strategies and planning/executing deliverables.
- Mentor and support junior staff and build a culture of support and collaboration.
BASIC QUALIFICATIONS
- PhD in Chemical/Biochemical/Biological Engineering or a related discipline with 2+ years of industry experience with mammalian expression of AAVs, purification and relevant analytical methods.
- Significant experience, knowledge and understanding of purification technologies and operations such as AKTA or automated protein purification chromatography, TFF or UF/DF, Depth filtration.
- Familiarity with the discovery and development of AAVs as therapeutics.
- Curiosity and passion for research with strong interest in synthetic biology and gene therapy, creative and flexible thinking.
- Ability to plan, organize, problem solve (troubleshoot), design experiments, work efficiently independently and in a multidisciplinary team.
- Excellent communication skills, written and oral.
PREFERRED QUALIFICATIONS
- Related manufacturing or process development experience in biotech industry.
- Experience with library screens is a plus.
Other Job Details:
- Last Date to Apply for Job: March 31, 2021
- Eligible for Relocation Package: YES
- Eligible for Employee Referral Bonus: YES
#LI-PFE
Sunshine Act
Pfizer reports payments and other transfers of value to health care providers as required by federal and state transparency laws and implementing regulations. These laws and regulations require Pfizer to provide government agencies with information such as a health care provider's name, address and the type of payments or other value received, generally for public disclosure. Subject to further legal review and statutory or regulatory clarification, which Pfizer intends to pursue, reimbursement of recruiting expenses for licensed physicians may constitute a reportable transfer of value under the federal transparency law commonly known as the Sunshine Act. Therefore, if you are a licensed physician who incurs recruiting expenses as a result of interviewing with Pfizer that we pay or reimburse, your name, address and the amount of payments made currently will be reported to the government. If you have questions regarding this matter, please do not hesitate to contact your Talent Acquisition representative.
EEO & Employment Eligibility
Pfizer is committed to equal opportunity in the terms and conditions of employment for all employees and job applicants without regard to race, color, religion, sex, sexual orientation, age, gender identity or gender expression, national origin, disability or veteran status. Pfizer also complies with all applicable national, state and local laws governing nondiscrimination in employment as well as work authorization and employment eligibility verification requirements of the Immigration and Nationality Act and IRCA. Pfizer is an E-Verify employer.
Research and Development
#LI-PFE
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