Principal Scientist, RNA Therapeutics

Cambridge, Massachusetts
February 19 2021
Position Type
Full Time
Organization Type
Why Patients Need You

Pfizer's purpose is to deliver breakthroughs that change patients' lives. Research and Development is at the heart of fulfilling Pfizer's purpose as we work to translate advanced science and technologies into the therapies and vaccines that matter most. Whether you are in the discovery sciences, ensuring drug safety and efficacy or supporting clinical trials, you will apply cutting edge design and process development capabilities to accelerate and bring the best in class medicines to patients around the world.

Role Summary

We are seeking a creative and driven senior candidate to lead development of RNA Therapeutic optimization platform in the BioMedicine Design (BMD) line of the Medicinal Sciences Organization. The candidate will capitalize on their experience with mRNA and self-replicating RNA to develop processes for optimization of RNA Therapeutics platform in the discovery space to support the RNA based therapy portfolio across Pfizer.

Role Responsibilities
  • Lead development of RNA therapeutics optimization platform.
  • Oversee and support different aspects of RNA production, transient expression and analysis.
  • Collaborate with groups across Pfizer to develop processes compatible with and capitalizing on existing internal knowledge/infrastructure.
  • Routinely generate top quality data packages and present at project meetings.
  • Propose experimental designs and work closely with cross-functional teams, project leads and senior group members on identifying/advancing best strategies and planning/executing deliverables.
  • Mentor and support junior staff and build a culture of support and collaboration.


  • PhD in Chemical/Biochemical/Biological Engineering or a related discipline with 2+ years of industry experience in the field of mRNA and self-replicating RNA engineering.
  • Significant experience with mammalian expression regulation and engineering.
  • Experience in cell culture, cell line maintenance, and various reporter assays (including flow cytometry).
  • Extensive experience with DNA and RNA manipulation (including recombinant DNA techniques, IVT, sequence analysis, DNA/RNA isolation, RT-qPCR/ddPCR, purification and analysis).
  • Experience with self-replicating RNA.
  • Curiosity and passion for research with strong interest in synthetic biology and gene therapy, creative and flexible thinking.
  • Ability to plan, organize, problem solve (troubleshoot), design experiments, work efficiently independently and in a multidisciplinary team.
  • Excellent communication skills, written and oral.

  • Experience with high throughput DNA assembly and/or cell-based assays.

Other Job Details:
  • Last Date to Apply for Job: March 31, 2021
  • Eligible for Employee Referral Bonus: YES

Sunshine Act

Pfizer reports payments and other transfers of value to health care providers as required by federal and state transparency laws and implementing regulations. These laws and regulations require Pfizer to provide government agencies with information such as a health care provider's name, address and the type of payments or other value received, generally for public disclosure. Subject to further legal review and statutory or regulatory clarification, which Pfizer intends to pursue, reimbursement of recruiting expenses for licensed physicians may constitute a reportable transfer of value under the federal transparency law commonly known as the Sunshine Act. Therefore, if you are a licensed physician who incurs recruiting expenses as a result of interviewing with Pfizer that we pay or reimburse, your name, address and the amount of payments made currently will be reported to the government. If you have questions regarding this matter, please do not hesitate to contact your Talent Acquisition representative.

EEO & Employment Eligibility

Pfizer is committed to equal opportunity in the terms and conditions of employment for all employees and job applicants without regard to race, color, religion, sex, sexual orientation, age, gender identity or gender expression, national origin, disability or veteran status. Pfizer also complies with all applicable national, state and local laws governing nondiscrimination in employment as well as work authorization and employment eligibility verification requirements of the Immigration and Nationality Act and IRCA. Pfizer is an E-Verify employer.

Research and Development


Similar jobs

Similar jobs