Sr. Principal Scientist/Principal Scientist, Structure Based Protein Analysis

Cambridge, Massachusetts
February 18 2021
Position Type
Full Time
Organization Type
Role summary

We are seeking a protein structure modeling expert to design industry-leading biotherapeutics as part of Pfizer's BioMedicine Design team. The successful candidate will join project teams to optimize protein-based therapeutic leads in early through late discovery, primarily using protein structure and molecular simulation. The candidate will also evaluate and create improved computational workflows. Other areas of opportunity may include data

analysis across programs to develop predictive models for pharmaceutical properties, and engineering improved protein scaffolds.


Works with project teams as a primary source of knowledge for structure-based computational analysis of protein biotherapeutic leads and provides optimized designs. Effectively communicates results and recommendations to colleagues with diverse scientific backgrounds. Evaluates/implements new or improved methods to increase throughput and/or accuracy of molecular modeling workflows. Analyzes data sets to discover relationships between protein structure and key pharmaceutical properties. Engineers improved general scaffolds for protein therapeutics.

  • PhD in biochemistry, chemistry, or a related field and experience in the biopharmaceutical industry.
  • Strong track record of structure-based engineering of protein properties (such as stability and binding partner affinity).
  • Expertise in one or more commonly used protein structure modeling software packages.
  • Programming in a Linux environment using a scripting language such as Perl or Python.

  • Working knowledge of antibody structure and function is a significant advantage.
  • Working knowledge of bioinformatics tools and databases.
  • Conducting research projects in a team setting, presenting results to scientists of varying technical backgrounds.
  • Linux systems administration skills and knowledge of HPC environments.
  • Experience with one or more of the following software suites: Schrodinger, Rosetta, Discovery Studio, FoldX.
  • Experience integrating multiple scientific software toolkits to develop new analysis workflows usable by colleagues.
  • Strong track record of publication in topics involving protein structure analysis.

Other Job Details:
  • Last Date to Apply for Job: April 30, 2021
  • Eligible for Employee Referral Bonus: YES


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EEO & Employment Eligibility

Pfizer is committed to equal opportunity in the terms and conditions of employment for all employees and job applicants without regard to race, color, religion, sex, sexual orientation, age, gender identity or gender expression, national origin, disability or veteran status. Pfizer also complies with all applicable national, state and local laws governing nondiscrimination in employment as well as work authorization and employment eligibility verification requirements of the Immigration and Nationality Act and IRCA. Pfizer is an E-Verify employer.

Research and Development


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