Research Fellow

The International Replication Repair Deficiency (RRD) Consortium, based at the Hospital for Sick Children, is dedicated to studying and advancing treatment for replication repair deficiency and its associated cancers.   We use genomics, functional genomics and animal models to study the initiation and progression of RRD cancers and translate these into novel immune-based therapies.

The work produced by the consortium has led to many high-impact papers, as well as two multi-center clinical trials centered at SickKids.

Based on our recent discoveries, and new mouse models, we are currently focusing on translating novel combinations to exploit RRD cancer vulnerabilities into international clinical trials.

We are looking for an eager and motivated postdoctoral fellow with previous experience with transgenic mouse models and therapeutics to join our group. Knowledge of genomic analysis, coding and preclinical testing is recommended. As a postdoctoral fellow, you will be the critical cornerstone of our translational therapy program and have the opportunity to work with our international collaborators to see how your research can have a direct impact on children’s health on a global scale.

Job Summary:

The successful candidate will be involved in bench research, in a lead, co-investigator and collaborative role. We are specifically looking for an individual who is capable of running complex experiments requiring partnerships between multiple lab members and international collaborators.

Your role will include, but not be limited to:

• Advancing our drug and genetic screens towards preclinical testing of immunotherapy drugs on syngeneic mice.
• Supervision and mentorship of students and junior technicians within the laboratory.
• Conducting and participating in basic bench research, animal work and bioinformatic analysis. 
• Acquiring knowledge in cancer genetics and integrating in vitro, in vivo and mouse data with human patient data. 
• Developing your professional and scientific acumen by engaging with global collaborators and stakeholders
• Maintain accurate records of data and protocols
• Works closely with the PI and other lab members to organize laboratory activities and group meetings
• Disseminating research and clinical findings through publications, presentations, and seminars.

We are looking for an eager and motivated postdoctoral fellow with previous experience with transgenic mouse models and therapeutics to join our group.

Knowledge of genomic analysis, coding and preclinical testing is recommended. As a postdoctoral fellow, you will be the critical cornerstone of our translational therapy program and have the opportunity to work with our international collaborators to see how your research can have a direct impact on children’s health on a global scale.

Here's What You'll Need:

• The successful applicant must hold a PhD degree
• Excellent molecular biology and bioinformatic skills
• Specific experience in mouse handling and colony management, mouse models of cancer, and cell culture systems
• Specific experience in generating and maintaining mouse xenografts is an asset.
• Knowledge of cancer genetics/epigenetics is an asset
• Motivation and the ability to work independently are required
• Strong verbal and written communication skills are a must
• Candidates who have obtained their PhD within the last two years will be preferred.

Employment Type: Temporary, Full-Time (one-year contract with possibility of renewal)