Post-Doctoral Scholar – Cardiovascular Research Institute

Location
Cleveland, Ohio (US)
Salary
NIH salary scale
Posted
January 26 2021
Position Type
Full Time
Organization Type
Academia
Job Type
Postdoc

Position Objective

The Case Cardiovascular Research Institute at Case Western Reserve University School of
Medicine and the Harrington Heart & Vascular Institute at University Hospitals seeks to hire a
post-doctoral fellow to conduct research in the laboratory of Dr. Rajagopalan. The Rajagopalan
lab studies metabolic changes, circadian rhythm, neurocognitive and epigenetic modifications
and their translational relevance to human diseases. The lab is particularly interested in the
immune interface of metabolic/circadian alterations and epigenetic control of these pathways.
We are developing novel approaches to probe cell-type specific epigenetic changes in complex
tissues using techniques including microdissection, fluorescence-activated nuclear sorting, DNA
methylation analysis by whole-genome bisulfite sequencing, and transcriptional profiling (e.g.,
RNA-seq and ChIP-seq, Bisulfite-seq).

This position will focus on the role of molecular control of immunity in diseases like
atherosclerosis and metabolic syndrome through circadian disruption and epigenetic
regulations. The applicant must have a PhD or MD/PhD in biomedical sciences with an
established record of peer reviewed publications. Interested individuals should send a cover
letter, CV, and contact information of three people who could provide recommendation letters of
reference by email to rodent1117a@gmail.com

ESSENTIAL FUNCTIONS

As a Postdoctoral Scholar, the candidate is expected to:

1. Play a leading role in the design, implementation, and analysis of experiments in mouse
models to improve our understanding of how epigenetic factors shape immune
responses, in response to environmental stressors.
2. Have a strong background in animal models and in-vivo physiology with an emphasis on
metabolic characterization.
3. Perform mouse experiments and husbandry including, breeding, genotyping and
maintain an accurate animal database.
4. Have expertise in FACS/Flow Sorting and single cell isolation approaches.
5. Rigorously document experimental results and present results in laboratory meetings,
departmental seminars and scientific conferences.
6. Prepare manuscripts and contribute preliminary data for grant proposals.
7. Work closely with other lab members to ensure projects are being completed according
to the research plan and in organizing laboratory space and supplies.

Experience with analytical approaches to high-volume genomic, epigenomic, and gene
expression data is a strong plus.

SUPERVISORY RESPONSIBILITIES
Train and oversee rotation students and other research staff in the lab.

EDUCATION REQUIREMENTS
PhD in Immunology or other biomedical sciences with bioinformatics research experience.

YEARS OF RELEVANT EXPERIENCE REQUIRED
PhD with 0-3 years of postdoctoral experience.

PROPOSED SALARY RANGE
NIH salary scale.

DESIRABLE SKILLS:

Experience in cell culture of primary mouse and human hematopoietic stem and progenitor
cells.
Experience in immunology techniques notably multi-panel flow cytometry.
Experience in molecular cloning, molecular & cell biology techniques.
Experience with handling and working on animal model experiments.
Ability to work independently after essential training has been provided.
Effective oral and written communication skills.
Flexibility in work schedule to complete necessary study within deadlines.

In employment, as in education, Case Western Reserve University is committed to Equal
Opportunity and Diversity. Women, veterans, members of underrepresented minority groups,
and individuals with disabilities are encouraged to apply.

Case Western Reserve University provides reasonable accommodations to applicants with
disabilities. Applicants requiring a reasonable accommodation for any part of the application and
hiring process should contact the Office of Inclusion, Diversity and Equal Opportunity at 216-
368-8877 to request a reasonable accommodation. Determinations as to granting reasonable
accommodations for any applicant will be made on a case-by-case basis.

Key words: bioinformatics, bisulfite-seq, diabetes, atherosclerosis, metabolism,
computational biology, DNA methylation, epigenetics, epigenome, epigenomic, circadian,
environment, human, hypothalamus, mammalian, mouse, neuroscience, next-generation
sequencing, nutrition, obesity, postdoc, physical activity.

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