Research Scientist - Immunology - ECLIPSE

Location
Houston, Texas
Salary
Competitive
Posted
February 24 2021
Ref
137455
Organization Type
Healthcare/Hospital
The mission of The University of Texas M. D. Anderson Cancer Center is to eliminate cancer in Texas, the nation, and the world through outstanding programs that integrate patient care, research and prevention, and through education for undergraduate and graduate students, trainees, professionals, employees and the public.

ECLIPSE (Evolution of Cancer, Leukemia and Immunity Project) is a novel organization within the MD Anderson Cancer Center, Houston, Texas, with the mission of making MDACC and its partners recognized leaders in the identification and development of innovative immunooncology therapies that will cure all hematologic malignancies. https://www.mdanderson.org/cancermoonshots/research_platforms/eclipse.html

We are seeking an experienced and highly motivated individual with deep expertise in Immunology to drive projects focused on the identification and validation of potential therapeutic targets for patients with advanced hematologic malignancies. The Institute Research Scientist will participate in cross-functional research developing and implementing state-of-the-art techniques to identify and validate novel immunotherapy targets for hematological malignancies. The selected candidate will be expected to work primarily at the bench, and must be able to independently design, execute, interpret, and troubleshoot experiments. Furthermore, the selected candidate will propose next steps and provide critical feedback on scientific plans.

Key responsibilities
• Optimize/implement cutting-edge high-throughput viral screening methods to identify novel immunotherapy targets.
• Use standard in vitro and ex vivo immunological techniques (e.g. primary T cell culture, flow cytometry, ELISA/MSD Assays, Cytotoxicity assays, qRT-PCR, peptide:MHC tetramer staining) to identify, characterize, and validate immunotherapy targets.
• Collaborate with cancer biology and computational biology team members on a discovery platform using high throughput multi-omic technologies; apply scientific expertise in immunology to drive these programs in a multidisciplinary and exciting research team environment.
• Independently design, execute, interpret, and troubleshoot experiments to answer key scientific questions. Use data to make decisions and new hypotheses.
• Keep abreast of current and emerging technological and scientific advancements in the field.

Education

Required: Master's degree in biology, biochemistry, molecular biology, cell biology, enzymology, pharmacology, chemistry or related field.

Preferred: PhD in Immunology or a related discipline.

Experience

Required: Six years experience of relevant research experience in laboratory With a PhD in a natural science or Medical degree, two years of required experience.

Preferred:

• Expertise in T cell biology
• Hands-on experience with primary T cell culture, flow cytometry, T cell functional assays
• Ability to independently design, execute, interpret, and troubleshoot experiments. Ability use results to propose and design follow-up experiments.
• Track-record of productivity, demonstrated by publication in respected, peer reviewed journals, and/or patent filings
• Excellent record keeping abilities. Ability to clearly communicate results to co-workers, collaborators, and leadership
• Expertise in leukemia biology
• Experience in molecular biology techniques such as PCR and qPCR assays
• Experience in virus production, and viral engineering of cells
• Experience with 10X genomics platform

It is the policy of The University of Texas MD Anderson Cancer Center to provide equal employment opportunity without regard to race, color, religion, age, national origin, sex, gender, sexual orientation, gender identity/expression, disability, protected veteran status, genetic information, or any other basis protected by institutional policy or by federal, state or local laws unless such distinction is required by law. http://www.mdanderson.org/about-us/legal-and-policy/legal-statements/eeo-affirmative-action.html

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