Pfizer

Principal Scientist - Clinical Biomarker Technologies, Flow Cytometry

Employer
Pfizer
Location
Groton, Connecticut
Salary
Competitive
Posted
January 22 2021
Ref
4801183
Position Type
Full Time
Organization Type
Pharma
ROLE SUMMARY

Principal Scientist (R5). Works with ECD scientific staff in scientific research and/or scientific strategies in a biomarker/biomeasure focused flow cytometry laboratory. This scientist will provide technical and scientific leadership and support for biomarker data using flow cytometry (FACS), cell imaging and related technologies for both non-regulated and regulated preclinical and clinical biomarker studies supporting Pfizer drug candidates. Leads and influences in the matrix function across ECD, RUs and BUs.

Responsibilities
  • Responsible for providing flow cytometry and cellular imaging data for biomarker/biomeasure discovery and development, supporting assay method development, validation and study execution.
  • Interact with biomarker sub-teams and research units in a matrix environment.
  • The person will demonstrate experience in the delivery of flow cytometry and cell imaging-based biomarkers/biomeasures in clinical studies, and have strong knowledge of biological systems, cellular functions and concepts in immunology to enable Pfizer discovery and development objectives.
  • Responsible for developing partnerships in a matrix environment, influencing project strategies, and providing expertise in technology development and implementation.
  • Lead the development of sample preparation, separation and detection methods, data analysis, interpretation, reporting and follow up discussions with the project teams on utilizing the data in appropriate decision making.
  • Responsible for maintaining regulatory compliance appropriate for clinical and preclinical study execution including all prescribed training as found in ECD SOPs and training transcripts.
  • This includes knowledge, training and understanding of GLP/GCP guidance for execution of preclinical and clinical studies supporting Pfizer portfolio projects as applicable.
  • Responsible for QC and peer review of raw data and results from colleagues and/or direct reports within the regulated group, as well as participation in internal and external audits providing required information to auditors as needed.
  • Mentor junior scientists in biomarker strategy development, experimental protocol optimization, troubleshooting, data generation and analysis.
  • Participate in continuous improvement of scientific and regulatory processes via update/creation of SOP's, design and implementation of laboratory and study based processes, and development of best practices for bioanalytical data generation.
  • Partners across lines (especially Clinical Pharmacology, Precision/Translational Medicine, DSRD, Pharmaceutical Sciences and Regulatory) to integrate flow and imaging-based biomarker data into an overall understanding of drug MOA and efficacy.


PHYSICAL/MENTAL REQUIREMENTS
  • Knowledge of the principles of flow cytometry, cell based imaging analysis and cell biology/immunology.
  • Experience operating flow cytometers/sorters.
  • Knowledge of assay development and sample processing for flow cytometric analysis.
  • Knowledge and experience of global regulatory requirements as well as industry guidance as they relate to GCLP.
  • Excellent oral and written communication skills.
  • Ability to coach and mentor colleagues in a matrix environment.
  • Ability to work in teams.


Other Job Details:
  • Eligible for Relocation Package: YES
  • Eligible for Employee Referral Bonus: YES


#LI-PFE

Sunshine Act

Pfizer reports payments and other transfers of value to health care providers as required by federal and state transparency laws and implementing regulations. These laws and regulations require Pfizer to provide government agencies with information such as a health care provider's name, address and the type of payments or other value received, generally for public disclosure. Subject to further legal review and statutory or regulatory clarification, which Pfizer intends to pursue, reimbursement of recruiting expenses for licensed physicians may constitute a reportable transfer of value under the federal transparency law commonly known as the Sunshine Act. Therefore, if you are a licensed physician who incurs recruiting expenses as a result of interviewing with Pfizer that we pay or reimburse, your name, address and the amount of payments made currently will be reported to the government. If you have questions regarding this matter, please do not hesitate to contact your Talent Acquisition representative.

EEO & Employment Eligibility

Pfizer is committed to equal opportunity in the terms and conditions of employment for all employees and job applicants without regard to race, color, religion, sex, sexual orientation, age, gender identity or gender expression, national origin, disability or veteran status. Pfizer also complies with all applicable national, state and local laws governing nondiscrimination in employment as well as work authorization and employment eligibility verification requirements of the Immigration and Nationality Act and IRCA. Pfizer is an E-Verify employer.

Research and Development

Similar jobs

Similar jobs