Senior Scientist -- Biological Mass Spectrometry

Pearl River, New York
January 22 2021
Position Type
Full Time
Organization Type
Job Type
Senior Scientist
Why Patients Need You

Pfizer's purpose is to deliver breakthroughs that change patients' lives. Research and Development is at the heart of fulfilling Pfizer's purpose as we work to translate advanced science and technologies into the therapies and vaccines that matter most. Whether you are in the discovery sciences, ensuring drug safety and efficacy or supporting clinical trials, you will apply cutting edge design and process development capabilities to accelerate and bring the best in class medicines to patients around the world.

The Bacterial Vaccines & Technology department within Pfizer is focused on the development of vaccines to prevent infectious disease. Though we specialize in bacterial vaccine development, the group also plays a supportive role for viral vaccine programs . The protein characterization group within the B-cell technology group assesses the biochemical properties of vaccine antigens including characterization of antibody binding. Several techniques are used for this effort including conventional mass spectrometry, hydrogen-deuterium exchange mass spectrometry, isothermal titration calorimetry, surface plasmon resonance and biolayer interferometry approaches.

What You Will Achieve

As a Senior Scientist, you will be embedded in our operations and your work will be part of the on-going vaccine research programs to deliver first in-class medicines in the upcoming years. You will be an essential member of the B-cell team, characterizing different types of antibodies and reagents for vaccine characterization.

With your deep knowledge of mass spectrometry approaches you will support the team specifically in characterization of the recombinant antibodies and antigens. Your creativity and experience will be essential for this task. Your ability to plan and coordinate will support the team to achieve short-term projects as well as long-term goals. Using your prior work experience, scientific judgement to adjust existing methods combined with consulting others will allow to streamline processes. With your scientific enthusiasm you will support the team to include new technologies into the existing process achieve new goals and timelines to help patients.

How You Will Achieve It
  • Provide intact mass analysis, peptide mapping and/or glycan profiling of purified antigens and antibodies.
  • Proteomic profiling of circulating antibodies.
  • Analyze, interpret and present data with the help of computer applications such as SigmaPlot, MS PowerPoint and other MS Office applications, software for MS data analysis (BioPharmaFInder, Protein Metrics software suite and others, as applicable), protein structure analysis and visualization (e.g., SwissPDB Viewer, DS Visualizer, PyMol).
  • Author reports and technical documents. Contribute portions of patents, regulatory documents or manuscripts as required.
  • Present data at internal and externalmeetings.
  • Actively collaborate with other scientists within the Vaccine Research organization and Pfizer as a whole.
  • Perform daily, weekly and monthly laboratory activities, such as periodic monitoring of equipment, periodic laboratory cleaning and managing the laboratory waste.
  • Satisfactorily complete all training in conformance with Departmental requirements. Where applicable, perform job responsibilities in compliance with cGMP/GLP and all other regulatory agency requirements.
  • Maintain a safe and productive work environment. Conducts all activities and makes decisions that are in accordance with Company policies & SOPs, Pfizer Values, & global regulatory guidelines, environmental guidelines, as appropriate.
  • Perform other duties, such as inventory documentation, as assigned.


  • Ph.D. in biochemistry, structural biology, protein engineering or equivalent with 2-4 years of postdoctoral experience with emphasis on mass spectrometry is required.
  • Strong background and extensive hands on experience with Thermo Scientific Orbitrap mass spectrometers and relevant data analysis software.
  • Experience in two or more of the following areas: protein intact mass analysis, peptide mapping, glycan profiling, glycosylation site mapping, proteomics.
  • Incumbent should be proficient in the use of Word processing, Excel, PowerPoint and other relevant software.
  • Good verbal and written communication skills (as evidenced by a strong publication record) are required.

  • Working knowledge of immunology, molecular and cell biology or protein purification experience is a plus.
  • Experience with hydrogen-deuteirum exchange mass spectrometry.

  • Sitting, standing, walking, light lifting (

  • Travel to regional, national and international meetings.
  • Adherence to safe work practices and procedures required.

Other Job Details:
  • Eligible for Relocation Package: YES
  • Eligible for Employee Referral Bonus: YES


Sunshine Act

Pfizer reports payments and other transfers of value to health care providers as required by federal and state transparency laws and implementing regulations. These laws and regulations require Pfizer to provide government agencies with information such as a health care provider's name, address and the type of payments or other value received, generally for public disclosure. Subject to further legal review and statutory or regulatory clarification, which Pfizer intends to pursue, reimbursement of recruiting expenses for licensed physicians may constitute a reportable transfer of value under the federal transparency law commonly known as the Sunshine Act. Therefore, if you are a licensed physician who incurs recruiting expenses as a result of interviewing with Pfizer that we pay or reimburse, your name, address and the amount of payments made currently will be reported to the government. If you have questions regarding this matter, please do not hesitate to contact your Talent Acquisition representative.

EEO & Employment Eligibility

Pfizer is committed to equal opportunity in the terms and conditions of employment for all employees and job applicants without regard to race, color, religion, sex, sexual orientation, age, gender identity or gender expression, national origin, disability or veteran status. Pfizer also complies with all applicable national, state and local laws governing nondiscrimination in employment as well as work authorization and employment eligibility verification requirements of the Immigration and Nationality Act and IRCA. Pfizer is an E-Verify employer.

Research and Development


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