Senior Scientist, Oncogene Networks

ROLE SUMMARY

mRNA translational control and protein synthesis play a crucial role in cancer development and progression. We are seeking an experienced molecular and cell biologist at the senior scientist level to contribute to the success of the Oncogenes Network group in Tumor Biology Department located in La Jolla, California, to play a key role in the development of novel anti-cancer therapies.

This is an exciting opportunity to contribute to precision medicine projects in protein translation control in cancer. Contribute to experimental drug discovery, target identification/validation, mechanism of action studies, identification of resistance mechanisms and combinatorial therapeutic regimens for cancer treatment. Employ cutting-edge in vitro methods and animal models.

Role Responsibilities:

• Strong laboratory background to design, conduct experiments, analyze and present molecular and cell biology mechanism of action studies, resistance mechanisms and develop novel combination concepts to support Oncology pipeline.
  
• Collaborate with Pfizer's world-class systems biology and computational biology groups to identify novel mechanisms and targets in protein translational control in cancer
• Work in a multi-disciplinary team to develop novel small molecule cancer therapeutics. Contribute to all stages of preclinical drug discovery and development.

Qualifications:

• Ph.D. in Biology, Cell Signaling or a related subject
• At least five years of cancer research experience with an emphasis in protein translational control in cancer; strong publication record or equivalent achievements in pharmaceutical or biotech industry.

Technical Skill Requirements:

• Proven ability to make important scientific contributions to protein translational control in cancer.
• Familiarity and strong expertise in methods used to understand resistance mechanisms and target identification and validation.
• Competence to stay on top of novel scientific developments and to identify quickly relevant new scientific field to make significant contributions.
• A proven high-level of technical competence and extensive experience in standard cell and molecular biology assays related to oncology are essential.
• Excellent written and oral communication and presentation skills in English. Proficiency in all common office and scientific software.
• Strong ability to work efficiently and productively in a fast-paced, highly collaborative and diverse team environment.

Preferred Qualifications:

• Experience in CRISPR approach for synthetic lethality screen is a plus

OTHER INFORMATION
•Relocation eligible
•Eligible for employee referral bonus

#LI-PFE

Sunshine Act

Pfizer reports payments and other transfers of value to health care providers as required by federal and state transparency laws and implementing regulations. These laws and regulations require Pfizer to provide government agencies with information such as a health care provider's name, address and the type of payments or other value received, generally for public disclosure. Subject to further legal review and statutory or regulatory clarification, which Pfizer intends to pursue, reimbursement of recruiting expenses for licensed physicians may constitute a reportable transfer of value under the federal transparency law commonly known as the Sunshine Act. Therefore, if you are a licensed physician who incurs recruiting expenses as a result of interviewing with Pfizer that we pay or reimburse, your name, address and the amount of payments made currently will be reported to the government. If you have questions regarding this matter, please do not hesitate to contact your Talent Acquisition representative.

EEO & Employment Eligibility

Pfizer is committed to equal opportunity in the terms and conditions of employment for all employees and job applicants without regard to race, color, religion, sex, sexual orientation, age, gender identity or gender expression, national origin, disability or veteran status. Pfizer also complies with all applicable national, state and local laws governing nondiscrimination in employment as well as work authorization and employment eligibility verification requirements of the Immigration and Nationality Act and IRCA. Pfizer is an E-Verify employer.

Research and Development