Senior Principal Scientist - Cell Line Development, BioProcess R&D

Chesterfield, Missouri
January 22 2021
Position Type
Full Time
Organization Type
Job Description

A Senior Principal Scientist position is available within the Cell Line Development (CLD) group in BioProcess R&D (BRD). The successful applicant will be responsible for the development and characterization of both mammalian and microbial cell lines for the clinical/ commercial manufacture of recombinant protein and vaccine products. They will be expected to provide strong technical, strategic, and organizational leadership, effectively manage a multi-project development portfolio and make strong technical and strategic contributions to multi-disciplinary/ cross-functional development project teams to ensure efficient and timely execution of CLD deliverables.

The Senior Principal Scientist will be a champion of innovation to ensure CLD's technology leadership. They will design and drive changes to CLD technologies, practices and infrastructure to ensure impactful organizational evolution and continuous technology improvements. The successful applicant will contribute to the development of robust, efficient, scalable strategies and technologies for improving the processes used to derive recombinant production cell lines, and the requisite productivity, stability and product quality outcomes.

This successful applicant will work effectively across organizational boundaries to establish strong working relationships with CLD "customers" including Research Units and Manufacturing partners, to promote efficient, integrated technologies and work-processes and seamless flow of information. This position will also work closely with the other BioProcess R&D functions to facilitate the timely delivery of cell lines to meet IND enabling Reg Tox and clinical supply objectives and will work across sites to ensure that best practices are employed.

The Senior Principal Scientist will be responsible for planning and developing a staff of 4-7 scientists. This role requires a highly motivated individual with the ability to work closely with other members of a laboratory group and the department in a matrix team environment, while maintaining a strong, collaborative culture. This role is responsible for helping to develop CLD staff through interpersonal connections and mentoring relationships - actively developing technical skills and identifying development opportunities so that all staff can grow and succeed.

The Senior Principal Scientist will be responsible for the preparation and review of internal technical reports and contribute to Regulatory Filings and responses to Regulatory questions, as appropriate. The position will also require oral presentations internally to scientists and management, and external presentations and publications as appropriate.


Candidate demonstrates a breadth of diverse leadership experiences and capabilities including: the ability to influence and collaborate with peers, develop and coach others, oversee and guide the work of other colleagues to achieve meaningful outcomes and create business impact.

  • PhD in molecular biology, cellular biology, biochemistry, or related field and 10+ years of experience, including possible postdoctoral training.
  • Experience with mammalian cell culture and recombinant protein production expected.
  • Strong theoretical understanding and practical experience with relevant scientific disciplines, particularly molecular biology/ cell biology/ microbiology/ biochemistry and application to creating and/ or characterizing recombinant mammalian and/or microbial cell lines.
  • Demonstrated leadership success in both project and people management and technology transfers.
  • Demonstrated ability to drive for results and lead innovation and change.
  • Collaborative, team-oriented leadership and management style essential.
  • Applicants should be bright, organized, self-motivated, and capable of working independently and in a collaborative, multi-site environment.
  • The successful candidate will possess strong oral and written communication skills.
  • Familiarity with relevant Regulatory Guidance documents and Regulatory paradigms and procedures.
  • Experience managing a group of scientists is a plus.

Other Job Details:
  • Eligible for Relocation Package: YES
  • Eligible for Employee Referral Bonus: YES


Sunshine Act

Pfizer reports payments and other transfers of value to health care providers as required by federal and state transparency laws and implementing regulations. These laws and regulations require Pfizer to provide government agencies with information such as a health care provider's name, address and the type of payments or other value received, generally for public disclosure. Subject to further legal review and statutory or regulatory clarification, which Pfizer intends to pursue, reimbursement of recruiting expenses for licensed physicians may constitute a reportable transfer of value under the federal transparency law commonly known as the Sunshine Act. Therefore, if you are a licensed physician who incurs recruiting expenses as a result of interviewing with Pfizer that we pay or reimburse, your name, address and the amount of payments made currently will be reported to the government. If you have questions regarding this matter, please do not hesitate to contact your Talent Acquisition representative.

EEO & Employment Eligibility

Pfizer is committed to equal opportunity in the terms and conditions of employment for all employees and job applicants without regard to race, color, religion, sex, sexual orientation, age, gender identity or gender expression, national origin, disability or veteran status. Pfizer also complies with all applicable national, state and local laws governing nondiscrimination in employment as well as work authorization and employment eligibility verification requirements of the Immigration and Nationality Act and IRCA. Pfizer is an E-Verify employer.

Research and Development


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